{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:35:18Z","timestamp":1776818118042,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Objectives<\/jats:title>Lower urinary tract symptoms (LUTS<\/jats:styled-content>) in men result from a complex interplay of pathophysiology, including bladder and bladder outlet dysfunction. This study retrospectively analyzed bladder dysfunction in men with LUTS<\/jats:styled-content> based on the results of video\u2010urodynamic studies (VUDS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Male patients (aged \u226540 years), with LUTS<\/jats:styled-content> and an International Prostate Symptom Score of 8 or more, who were refractory to alpha\u2010blocker treatment were retrospectively recruited and evaluated with VUDS<\/jats:styled-content> and total prostate volume (TPV<\/jats:styled-content>). Patients were further divided into subgroups of bladder dysfunction and bladder outlet dysfunction according to characteristic VUDS<\/jats:styled-content> findings. Age, TPV<\/jats:styled-content> and VUDS<\/jats:styled-content> findings were compared among different subgroups.<\/jats:p><\/jats:sec>Results<\/jats:title>After VUDS<\/jats:styled-content>, bladder outlet obstruction (BOO<\/jats:styled-content>) was only noted in 48.6% of men. Of patients, 919 of 2991 (30.7%) had bladder dysfunction including detrusor underactivity (DU<\/jats:styled-content>, 5.1%), detrusor overactivity and inadequate contractility (DHIC<\/jats:styled-content>, 5.3%), detrusor overactivity (DO<\/jats:styled-content>, 17%) and hypersensitive bladder (HSB<\/jats:styled-content>, 3.3%). In addition, 1941 (64.9%) had bladder outlet dysfunction including BOO<\/jats:styled-content> + DO<\/jats:styled-content> (33.8%), BOO<\/jats:styled-content> alone (14.8%), and poor urethral sphincter relaxation (PRES<\/jats:styled-content>, 16.3%). Among the 1519 patients with DO<\/jats:styled-content>, 66.6% (1012) had BOO<\/jats:styled-content> while, among 1454 patients with BOO<\/jats:styled-content>, 69.5% (1010) had DO<\/jats:styled-content>. Patients with DHIC<\/jats:styled-content>, DU<\/jats:styled-content> and DO<\/jats:styled-content> were 5 years older than patients with HSB<\/jats:styled-content> and normal men. TPV<\/jats:styled-content> was significantly smaller in patients with DHIC<\/jats:styled-content>, DU<\/jats:styled-content> and DO<\/jats:styled-content> as compared with BOO<\/jats:styled-content> + DO<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Approximately one\u2010third of male LUTS<\/jats:styled-content> was due to bladder dysfunction. A man older than 70 years with LUTS<\/jats:styled-content> and TPV<\/jats:styled-content> less than 30 mL usually indicates the presence of bladder dysfunction rather than BOO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12139","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T15:36:39Z","timestamp":1467387399000},"page":"32-37","source":"Crossref","is-referenced-by-count":16,"title":["Role of Bladder Dysfunction in Men with Lower Urinary Tract Symptoms Refractory to Alpha\u2010blocker Therapy: A Video\u2010urodynamic Analysis"],"prefix":"10.1111","volume":"10","author":[{"given":"Yuan\u2010Hong","family":"JIANG","sequence":"first","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Hou","family":"LIAO","sequence":"additional","affiliation":[{"name":"Department of Urology, Cardinal Tien Hospital Fu\u2010Jen Catholic University New Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hann\u2010Chorng","family":"KUO","sequence":"additional","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02228.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/luts.12067","article-title":"Role of bladder neck and urethral sphincter dysfunction in men with persistent bothersome lower urinary tract symptoms after alpha\u20101 blocker therapy","volume":"7","author":"Ke 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