{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:05:52Z","timestamp":1779347152293,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:00:00Z","timestamp":1486166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Objectives<\/jats:title>To evaluate changes over time in subjective symptom scores and urination parameters before and after oral administration of formulated food containing a combination of P<\/jats:styled-content>eucedanum japonicum<\/jats:italic> (P<\/jats:styled-content>. japonicum<\/jats:italic>) extract and saw palmetto extract (SPE<\/jats:styled-content>) in male patients with lower urinary tract symptoms (LUTS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This study was conducted in an open label manner on male patients with untreated LUTS<\/jats:styled-content>. The urination state of patients was evaluated before and after administration of food formulated with P<\/jats:styled-content>. japonicum<\/jats:italic> extract and SPE<\/jats:styled-content> for 4\u2009weeks, based on urodynamic parameters and subjective symptom scores (I<\/jats:styled-content>nternational P<\/jats:styled-content>rostate S<\/jats:styled-content>ymptom S<\/jats:styled-content>core [IPSS<\/jats:styled-content> and IPSS\u2010QOL<\/jats:styled-content>], O<\/jats:styled-content>veractive B<\/jats:styled-content>ladder S<\/jats:styled-content>ymptom S<\/jats:styled-content>core [OABSS<\/jats:styled-content>], O<\/jats:styled-content>veractive B<\/jats:styled-content>ladder Q<\/jats:styled-content>uestionnaire [OAB<\/jats:styled-content>\u2010q], and I<\/jats:styled-content>nternational I<\/jats:styled-content>ndex of E<\/jats:styled-content>rectile F<\/jats:styled-content>unction [IIEF<\/jats:styled-content>]).<\/jats:p><\/jats:sec>Results<\/jats:title>After the administration of food formulated with these extracts, the following results were obtained: (i) S<\/jats:styled-content>ubjective findings: T<\/jats:styled-content>he IPSS\u2010QOL<\/jats:styled-content> score improved significantly; both parameters related to nocturia, i.e., frequency of nighttime urination and OABSS<\/jats:styled-content>\u20102, improved significantly; other ratings for subjective symptoms slightly improved. (ii) Objective findings: R<\/jats:styled-content>esidual urine volume decreased significantly, and blood prostate specific antigen (PSA<\/jats:styled-content>) and urinary 8\u2010OHdG<\/jats:styled-content> levels decreased slightly after the treatment. (iii) Other findings: B<\/jats:styled-content>lood pressure decreased slightly. No adverse drug reactions were reported. (iv) Patient impressions: 75% of patients gave a rating of \u201cG<\/jats:styled-content>ood\u201d or higher, with 15 out of 20 patients wanting to continue treatment after the end of 4\u2010week administration period.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Food formulated with P<\/jats:styled-content>. japonicum<\/jats:italic> extract and SPE<\/jats:styled-content> may be useful to decrease frequency of nighttime urination and residual urine volume in male patients with LUTS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12155","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T10:22:41Z","timestamp":1486203761000},"page":"167-174","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Effects of Formulated Food of P<\/scp>eucedanum japonicum<\/i> Extract and Saw Palmetto Extract in Male Patients with Lower Urinary Tract Symptoms"],"prefix":"10.1111","volume":"10","author":[{"given":"Shinji","family":"KAGEYAMA","sequence":"first","affiliation":[{"name":"Kageyama Urology Clinic Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"BEPPU","sequence":"additional","affiliation":[{"name":"Beppu Nephrology and Urology Clinic Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"OHNOGI","sequence":"additional","affiliation":[{"name":"Takara Bio Inc. Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"MIYAZAKI","sequence":"additional","affiliation":[{"name":"Center for Pharma\u2010Food Research, Graduate School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"HARUNO","sequence":"additional","affiliation":[{"name":"Center for Pharma\u2010Food Research, Graduate School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"ITO","sequence":"additional","affiliation":[{"name":"Center for Pharma\u2010Food Research, Graduate School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuo","family":"YAMADA","sequence":"additional","affiliation":[{"name":"Center for Pharma\u2010Food Research, Graduate School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"50","article-title":"The background and present condition of urological guideline","volume":"1","author":"Oshima S","year":"2003","journal-title":"Urological View"},{"key":"e_1_2_7_3_1","first-page":"178","article-title":"Epidemiologic survey on lower urinary tract symptoms in Japan","volume":"15","author":"Homma Y","year":"2003","journal-title":"J Jpn Continence Soc"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06574.x"},{"key":"e_1_2_7_5_1","volume-title":"Plants of the Yaku Island","author":"Hatsushima S","year":"2003"},{"key":"e_1_2_7_6_1","volume-title":"Makino's Pictorial Book of Japanese and Chinese Medicinal Herbs in Full\u2010color Illustrations","author":"Okada M","year":"2002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.10.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(95)00625-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34934"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0349127"},{"key":"e_1_2_7_11_1","first-page":"81","article-title":"Anti\u2010atherosclerotic and vasorelaxant effects of Peucedanum japonicum on Yaku Island","volume":"48","author":"Ohnogi H","year":"2013","journal-title":"Food Process Ingredients"},{"key":"e_1_2_7_12_1","first-page":"28","article-title":"Extract of Peucedanum japonicum, an umbelliferae plant, alleviated acetic acid\u2010induced hypertensive bladder response in rats","volume":"32","author":"Ito Y","year":"2013","journal-title":"Neurourol Urodyn"},{"key":"e_1_2_7_13_1","unstructured":"KageyamaS.Clinical effects ofPeucedanum japonicumin Patients with overactive bladder.Presentation in S3\u20102 at the 64th Annual Meeting of the Central Section of the Japanese Urological Association; Hamamatsu Japan 2015(in Japanese)."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67631-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16496"},{"key":"e_1_2_7_16_1","first-page":"69","article-title":"Proataglandin content in proatatic adenomas after treatment with a sterol","volume":"98","author":"Zahradnik HF","year":"1980","journal-title":"Fortschr Med"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.9.284"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000146273.26591.f5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1625\/jcam.4.41"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.02.038"},{"key":"e_1_2_7_21_1","volume-title":"Clinical Guideline for Prostatic Hyperplasia","author":"The Japanese Urological Association","year":"2011"},{"key":"e_1_2_7_22_1","volume-title":"Clinical Guideline for Nocturia","author":"The Japanese Urological Association","year":"2009"},{"key":"e_1_2_7_23_1","first-page":"10","article-title":"Analysis of 8\u2010hydroxydeoxyguanosine as a marker of oxidative stress","volume":"194","author":"Kasai H","year":"2001","journal-title":"Foods Food Ingredients J Jpn"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.39.507"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:52:36Z","timestamp":1695563556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,4]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/luts.12155"],"URL":"https:\/\/doi.org\/10.1111\/luts.12155","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,4]]}}}