{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:37:28Z","timestamp":1761129448474,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study evaluates the diagnostic value of poorly relaxed external sphincter (PRES) in men with voiding dysfunction. We analyzed clinical and video\u2010urodynamic characteristics to identify predictive factors of PRES in patients with lower urinary tract symptoms (LUTS) refractory to \u03b1\u20101 adrenoceptor blocker (\u03b1\u2010blocker) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 3379 men with LUTS in whom the initial 1\u2010month \u03b1\u2010blocker therapy failed. Clinical parameters and video\u2010urodynamic results were analyzed. Patients with bladder outlet disorders including bladder neck obstruction (BNO), benign prostatic obstruction (BPO), urethral stricture (US), or PRES were categorized according to video\u2010urodynamic findings. Predictive factors for PRES were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3379 men were included in this study. Among the patients with voiding dysfunction, 905 (43.6%) had BPO, 624 (30.0%) had BNO, 487 (23.4%) had PRES, and 62 (3.0%) had US. Patients with PRES were younger and had a higher maximum flow rate, larger bladder capacity, smaller total prostate volume (TPV) and transition zone index, and a lower rate of LUTS of urgency or urge urinary incontinence (UUI) than other groups. On multivariate analysis, only small TPV and lower urgency\/UUI rate were predictive factors of PRES. A scale composed of voided volume, TPV, and urgency\/UUI predicted PRES with high specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PRES was the etiology of voiding dysfunction in 23.4% of the men with LUTS refractory to \u03b1\u2010blocker therapy. A simple scale composed of voiding volume, TPV, and urgency\/UUI was useful in predicting the presence of PRES before video\u2010urodynamic studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12187","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T05:27:49Z","timestamp":1503638869000},"page":"8-13","source":"Crossref","is-referenced-by-count":4,"title":["Role of poor urethral sphincter relaxation in men with voiding dysfunction refractory to \u03b1\u2010blocker therapy: Clinical characteristics and predictive factors"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-0113","authenticated-orcid":false,"given":"I\u2010Hung","family":"Shao","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery Lotung Poh\u2010Ai Hospital  Yilan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology, Buddhist Tzu Chi General Hospital Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02228.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13073-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990170308"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12067"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.03.063"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68947-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00038-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49637-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01952307.1993.11735903"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)55307-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)55305-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121554"},{"issue":"1","key":"e_1_2_6_15_1","first-page":"24","article-title":"Treatment of detrusor\u2010sphincter dyssynergia with botulinum A toxin: a double\u2010blind study","volume":"71","author":"Dykstra DD","year":"1990","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)42717-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(10)60008-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.02.017"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68080-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-002-0309-9"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:15:33Z","timestamp":1694657733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,25]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/luts.12187"],"URL":"https:\/\/doi.org\/10.1111\/luts.12187","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"type":"print","value":"1757-5664"},{"type":"electronic","value":"1757-5672"}],"subject":[],"published":{"date-parts":[[2017,8,25]]}}}