{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:26:03Z","timestamp":1775550363137,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the present study was to analyze treatment outcomes and identify videourodynamic factors predictive of successful urethral onabotulinumtoxin<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> treatment of neurogenic and non\u2010neurogenic detrusor underactivity (<jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content> refractory to medical treatment were treated with injections totaling 100\u2009U onabotulinumtoxin<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> into the urethral sphincter. Treatment outcomes were assessed 1\u2009month after treatment using the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lobal <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>esponse <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment. The videourodynamic parameters evaluated included bladder neck status during voiding, bladder sensation, detrusor pressure, maximum flow rate, and post\u2010void residual volume. Treatment outcome was analyzed by patient and baseline videourodynamic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 60 patients (27 with non\u2010neurogenic and 33 with neurogenic <jats:styled-content style=\"fixed-case\">DU)<\/jats:styled-content> were included in the study and received urethral sphincter injections of 100\u2009U onabotulinumtoxin<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> in total. Good outcomes were reported in 36 (60%) patients (20 [74.1%] with non\u2010neurogenic and 16 [48.5%] with neurogenic <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>). Treatment outcome was significantly better in patients with non\u2010neurogenic than neurogenic <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u2009.039). However, good treatment outcome was not related to age, gender, or any videourodynamic variables, except for an open bladder neck during voiding vs non\u2010opening bladder neck (94.3% vs. 12.0%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). The duration of the therapeutic effect was similar between patients with non\u2010neurogenic and neurogenic <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content> (mean [\u00b1\u2009SD] 7.37\u2009\u00b1\u20093.69 vs. 7.69\u2009\u00b1\u20093.18\u2009months, respectively; <jats:italic>P<\/jats:italic>\u2009=\u2009.788). In all, 12 patients reported <jats:italic>de novo<\/jats:italic> urinary incontinence after urethral onabotulinumtoxin<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> injection, 4 of whom developed stress urinary incontinence and 8 who had exacerbated urgency urinary incontinence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Urethral sphincter injection of onabotulinumtoxin<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> is effective in 60% of patients with <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>. Careful videourodynamic interpretation of bladder neck opening enables urologists to select appropriate candidates for onabotulinumtoxin<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12195","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T09:12:38Z","timestamp":1507713158000},"page":"66-71","source":"Crossref","is-referenced-by-count":21,"title":["Videourodynamic factors predictive of successful onabotulinumtoxin<scp>A<\/scp> urethral sphincter injection for neurogenic or non\u2010neurogenic detrusor underactivity"],"prefix":"10.1111","volume":"11","author":[{"given":"Yuan\u2010Hong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Fong","family":"Jhang","sequence":"additional","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien 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