{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:05:43Z","timestamp":1770595543544,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study assessed the effectiveness and safety of a medical device containing purified bovine colostrum (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>onurelle <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>iogel; Zambon, Bresso, Italy) in improving vulvovaginal atrophy (<jats:styled-content style=\"fixed-case\">VVA<\/jats:styled-content>), sexual function, urinary symptoms, and quality of life (QoL) in postmenopausal women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 172 postmenopausal women with <jats:styled-content style=\"fixed-case\">VVA were included in the study<\/jats:styled-content>. All women were treated with vaginal <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>onurelle <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>iogel daily for 12\u2009weeks. Patients underwent clinical examinations, completed a 3\u2010day voiding diary, and had VVA graded using the <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>aginal <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">VHI<\/jats:styled-content>) at baseline and 12\u2009weeks. Patients also completed the Female Sexual Function Index (FSFI), overactive bladder questionnaire (<jats:styled-content style=\"fixed-case\">OAB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Q)<\/jats:styled-content>, and the Urogenital Distress Inventory (UDI\u20106), among others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12\u2009weeks, there were significant increases in mean (\u00b1 SD) <jats:styled-content style=\"fixed-case\">VHI<\/jats:styled-content> (12.53\u2009\u00b1\u20093.67 vs. 19.31\u2009\u00b1\u20093.49; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), the number of patients engaging in regular sexual activity 102 (59.3%) vs. 144 (83.7%), and in the total <jats:styled-content style=\"fixed-case\">FSFI<\/jats:styled-content> score (21.64\u2009\u00b1\u20092.99 vs. 28.16\u2009\u00b1\u20091.93; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) compared with baseline. In addition, there were significant reductions in the mean number of 24\u2010hour voids (9.57\u2009\u00b1\u20092.12 vs. 7.13\u2009\u00b1\u20091.22; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), urgent micturition episodes per 24\u2009hours (1.75\u2009\u00b1\u20090.76 vs. 1.14\u2009\u00b1\u20090.87; <jats:italic>P<\/jats:italic>\u2009=\u2009.001), nocturia episodes (1.58\u2009\u00b1\u20090.85 vs. 0.97\u2009\u00b1\u20091.18; <jats:italic>P<\/jats:italic>\u2009=\u2009.0002), and urinary incontinence episodes per 24\u2009hours (0.74\u2009\u00b1\u20090.59 vs. 0.28\u2009\u00b1\u20090.52; <jats:italic>P<\/jats:italic>\u2009=\u2009.003). Finally, after 12\u2009weeks treatment, there were significant differences in <jats:styled-content style=\"fixed-case\">UDI<\/jats:styled-content>\u20106 (7.85\u2009\u00b1\u20090.81 vs. 5.56\u2009\u00b1\u20091.40), <jats:styled-content style=\"fixed-case\">OAB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content> symptom (53.60\u2009\u00b1\u200912.57 vs. 22.08\u2009\u00b1\u20099.63), and <jats:styled-content style=\"fixed-case\">OAB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content> health\u2010related QoL (21.75\u2009\u00b1\u20098.51 vs. 69.34\u2009\u00b1\u200914.59) scores compared with baseline (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001 for all). The Patient Impression of Global Improvement scale revealed global improvement in 143 women (83.14%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>onurelle <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>iogel is an effective treatment for <jats:styled-content style=\"fixed-case\">VVA<\/jats:styled-content> in postmenopausal women, improving sexual life, urinary symptoms, and QoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12204","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T07:34:53Z","timestamp":1508744093000},"source":"Crossref","is-referenced-by-count":14,"title":["A medical device containing purified bovine colostrum (<scp>M<\/scp>onurelle <scp>B<\/scp>iogel) in the treatment of vulvovaginal atrophy in postmenopausal women: <scp>R<\/scp>etrospective analysis of urinary symptoms, sexual function, and quality of life"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-170X","authenticated-orcid":false,"given":"M. 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