{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:23:48Z","timestamp":1777055028435,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a debilitating chronic disease. There are few treatment options for IC\/BPS refractory to current medical therapy. This study investigated the clinical efficacy of intravesical injections of platelet\u2010rich plasma (PRP) in IC\/BPS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients with IC\/BPS received 4 intravesical injections, at 1\u2010monthly intervals, of 12\u2009mL PRP extracted from 50\u2009mL of the patient's whole blood, followed by cystoscopic hydrodistention. The primary endpoint was the change in O\u2019Leary\u2010Sant symptom (OSS) index from baseline to 1\u2009month after the 4th PRP injection. Secondary endpoints were changes in pain (measured using a visual analog scale [VAS]), daily frequency, nocturia, functional bladder capacity (FBC), maximum flow rate, voided volume, post\u2010void residual (PVR) volume, and global response assessment (GRA). Urinary cytokine levels were measured at baseline and 1\u2009month after the 1st PRP treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 15 women in the study, 13 completed the 4 injections and follow\u2010up visits (mean [\u00b1 SD] age 52.9\u2009\u00b1\u200912.1\u2009years). The OSS index and VAS pain score decreased significantly and FBC and GRA increased after the 1st PRP injection and lasted until the final endpoint. There was no change in PVR after repeated PRP injections, and all patients were free of urinary tract infections and difficulty urinating. Urinary interleukin (IL)\u20102 and IL\u20108 concentrations increased significantly after the 1st PRP injection. In patients with reductions in the VAS pain score \u22651, urinary IL\u20108 and vascular endothelial growth factor increased. In patients without reductions in the VAS pain score, IL\u20106 concentrations increased after PRP injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Repeated intravesical PRP injections are well tolerated and appear to be safe and effective in medically refractive IC\/BPS, providing significant symptom improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12212","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T05:28:38Z","timestamp":1513661318000},"source":"Crossref","is-referenced-by-count":30,"title":["Repeated intravesical injections of platelet\u2010rich plasma are effective in the treatment of interstitial cystitis: a case control pilot study"],"prefix":"10.1111","volume":"11","author":[{"given":"Jia\u2010Fong","family":"Jhang","sequence":"first","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien 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