{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:52:09Z","timestamp":1791870729016,"version":"4.3.4"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,11]],"date-time":"2018-03-11T00:00:00Z","timestamp":1520726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Two 31\u2010year\u2010old women who had abused ketamine, 1 for 8 years and 1 for 5 years, presented with ketamine\u2010induced vesicopathy with urinary frequency, decreased bladder capacity, and detrusor overactivity. An enterocystoplasty was performed in both cases. The pathology of the urinary bladders in both women showed ulcerative cystitis and fibrinoid necrosis of vessels; the latter was confirmed by Masson trichrome staining. Fibrinoid necrosis of vessels is a kind of immune complex\u2010mediated vasculitis that induces the release of inflammatory mediators, with subsequent thrombosis, ischemic injury, and eventual tissue necrosis in localized areas, the so\u2010called Arthus reaction. The new finding of fibrinoid necrosis in the urinary bladders of ketamine abusers may provide a new clue to the pathogenesis of ketamine\u2010induced vesicopathy.<\/jats:p>","DOI":"10.1111\/luts.12221","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T04:06:38Z","timestamp":1520827598000},"source":"Crossref","is-referenced-by-count":6,"title":["Vascular fibrinoid necrosis in the urinary bladder of ketamine abusers: A new finding that may provide a clue to the pathogenesis of ketamine\u2010induced vesicopathy"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-904X","authenticated-orcid":false,"given":"Yen\u2010Chang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology Hualien Tzu Chi Hospital and Buddhist Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Fong","family":"Jhang","sequence":"additional","affiliation":[{"name":"Department of Urology Hualien Tzu Chi Hospital and Buddhist Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Hsiang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pathology Hualien Tzu Chi Hospital and Buddhist Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology Hualien Tzu Chi Hospital and Buddhist Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,11]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"468","article-title":"Ketamine: a new look to an old drug","volume":"69","author":"Ivani G","year":"2003","journal-title":"Minerva Anesthesiol"},{"key":"e_1_2_4_3_1","first-page":"27","article-title":"Ketamine induced vesicopathy: a literature review","volume":"65","author":"Seshikanth M","year":"2010","journal-title":"IJCP"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07920.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-64"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12841"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160578"},{"key":"e_1_2_4_8_1","first-page":"44","volume-title":"Robbins and Cotran Pathologic Basis of Disease","author":"Vinay K","year":"2015"},{"key":"e_1_2_4_9_1","first-page":"185","volume-title":"Robbins and Cotran Pathologic Basis of Disease","author":"Vinay K","year":"2015"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.11.007"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/luts.12221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:20:03Z","timestamp":1694391603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,11]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/luts.12221"],"URL":"https:\/\/doi.org\/10.1111\/luts.12221","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,11]]}}}