{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:22:33Z","timestamp":1774362153175,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the efficacy and safety of mirabegron in elderly patients with urodynamic detrusor hyperactivity with impaired contractility (DHIC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with DHIC received daily dose of mirabegron (25mg). Subjective symptom scores, uroflowmetry data, and adverse events (AEs) were recorded for all patients at baseline and after 1, 3, and 6 months treatment. Comparisons were made for each patient individually and between patients with detrusor overactivity (DO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 65 patients enrolled in the study, 25 had DHIC and 40 had DO (mean [\u00b1 SD] age 79.3\u2009\u00b1\u20099.6 and 75.6\u2009\u00b1\u200910.7\u2009years, respectively). At the 6\u2010month follow\u2010up, significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) improvement was seen compared with baseline in both the DHIC and DO groups in terms of OAB symptom scores (4.72\u2009\u00b1\u20093.05 vs. 6.88\u2009\u00b1\u20094.06 and 4.50\u2009\u00b1\u20092.99 vs. 6.70\u2009\u00b1\u20093.60, respectively), urgency severity score (1.90\u2009\u00b1\u20092.00 vs. 3.35\u2009\u00b1\u20091.13 and 1.58\u2009\u00b1\u20091.93 vs. 3.00\u2009\u00b1\u20091.65, respectively), and global response assessment (1.80\u2009\u00b1\u20091.41 and 1.73\u2009\u00b1\u20091.34, respectively). In the DHIC group, post\u2010void residual (PVR) volume decreased from 153\u2009\u00b1\u200952.7\u2009mL at baseline to 85.8\u2009\u00b1\u200990.1\u2009mL at 6th month (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) and voiding efficiency improved from 40.0\u2009\u00b1\u200920.7% to 62.6\u2009\u00b1\u200928.3% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Common AEs included dry mouth and dizziness, yet 16% of DHIC patients developed PVR &gt;180\u2009mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mirabegron was an effective treatment option in elderly patients with urodynamic DO and DHIC in the present study. The AEs reported were mild and infrequent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12224","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T10:00:42Z","timestamp":1524736842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of mirabegron, a \u03b2<sub>3<\/sub>\u2010adrenoceptor agonist, in patients with detrusor hyperactivity and impaired contractility"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-2895","authenticated-orcid":false,"given":"Cheng\u2010Ling","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1001\/jama.1987.03390220074024","article-title":"Detrusor hyperactivity with impaired contractile function: an unrecognized but common cause of incontinence in elderly patients","volume":"257","author":"Resnick 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