{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:05:28Z","timestamp":1778918728660,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of solifenacin and mirabegron on vesical and urethral function were compared in rats with or without spinal cord injury (SCI). Isovolumetric cystometry and urethral pressure recording were initially performed in intact rats. Then, the bladder neck was ligated under urethane anesthesia, after which a catheter was inserted through the bladder dome for isovolumetric cystometry and another catheter was inserted into the urethra to measure urethral pressure. Solifenacin (0.03\u20133 mg\/kg) or mirabegron (0.03\u20133 mg\/kg) was injected intravenously, and bladder and urethral activity were recorded. To create rats with SCI, the spinal cord was transected at the lower thoracic level under isoflurane anesthesia. After 2 weeks, a catheter was inserted through the bladder dome for single cystometry and bladder activity was recorded without anesthesia following intravenous injection of solifenacin or mirabegron. Isovolumetric cystometry revealed a larger decrease in maximum bladder contraction pressure after injection of solifenacin, whereas prolongation of the interval between bladder contractions was greater with mirabegron. In SCI rats, single cystometry showed that solifenacin and mirabegron both increased bladder volume at the first non\u2010voiding bladder contraction and decreased the maximum bladder contraction pressure. Mirabegron also increased the voided volume and decreased the percentage residual volume without altering bladder capacity. Solifenacin and mirabegron both inhibited bladder contractility, and mirabegron possibly also induced urethral relaxation. Mirabegron may be suitable for patients with overactive bladder and residual urine.<\/jats:p>","DOI":"10.1111\/luts.12279","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T07:53:58Z","timestamp":1565164438000},"page":"92-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mirabegron causes vesical and urethral relaxation in rats with spinal cord injury"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5653-6563","authenticated-orcid":false,"given":"Kimio","family":"Sugaya","sequence":"first","affiliation":[{"name":"Southern Knights' Laboratory  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Kadekawa","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Ueda","sequence":"additional","affiliation":[{"name":"Institute for Animal Experiments, Faculty of Medicine University of the Ryukyus  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Graduate School of Medicine University of the Ryukyus  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22505"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12053"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09R13FM"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287214526768"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.02.023"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.060"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287212457114"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.11.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-16499-6_15"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-16499-6_16"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000074622.50255.a8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.115840"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13367"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.08.056"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0814-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.54"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1757-5672.2009.00049.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666020-00004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07031.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07939.x"},{"key":"e_1_2_6_22_1","first-page":"147","article-title":"Impact of mirabegron extended\u2010release on the treatment of overactive bladder with urge urinary incontinence, urgency, and frequency","volume":"5","author":"Lee RT","year":"2013","journal-title":"Res Rep Urol"},{"key":"e_1_2_6_23_1","first-page":"631","volume-title":"Incontinence. 4th Edition. 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