{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:50:30Z","timestamp":1773906630665,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to assess long\u2010term efficacity of botulinum neurotoxin A (BoNT\u2010A) in the treatment of neurogenic detrusor overactivity (NDO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a retrospective monocentric study in a reference center. We included patients who received intradetrusor BoNT\u2010A for NDO between 2001 and 2015. The focus of our analysis was on patients defined as \u201cgood responders\u201d (\u2265\u20095 injections of intradetrusor BoNT\u2010A over a period of \u22655\u2009years). The primary endpoint was the evaluation of long\u2010term efficacity of BoNT\u2010A. Recurrent NDO was monitored by the use of cystomanometry before the first injection and 1 month after each injection.<\/jats:p><jats:p>The secondary objective was to assess the influence of NDO's etiology, age, and sex on the long\u2010term efficacity of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 107 patients were included (60.7% with spinal cord injury [SCI] and 36.4% with multiple sclerosis [MS]). The mean follow\u2010up period was 83.7\u2009months (66; 120). The mean number of injections was of 8.9 (5; 21). A total of 67.3% (n = 72) of patients were still controlled by treatment at the end of their follow\u2010up period. Therapeutic failure occurred in 30 patients (26.1%) with a cessation of BoNT\u2010A treatment at 76 months on average (median: 82.5\u2009months). There was no significant impact of age (<jats:italic>P<\/jats:italic> = .42), sex (<jats:italic>P<\/jats:italic> = .35), or NDO's etiology (MS vs SCI; <jats:italic>P<\/jats:italic> = .54) on long\u2010term efficacy of BoNT\u2010A treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of our study indicate that the application of BoNT\u2010A seems to be an effective and durable treatment in a large number of neurogenic patients after more than 10\u2009years of follow\u2010up. However, botulinum toxin tolerance occurred in approximately 25% of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12297","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T19:50:08Z","timestamp":1576785008000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["How long does the effect of botulinum toxin in neurogenic patients last? An analysis of the subset of \u201cgood responders\u201d"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-7290","authenticated-orcid":false,"given":"In\u00e8s","family":"Dominique","sequence":"first","affiliation":[{"name":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Tremblais","sequence":"additional","affiliation":[{"name":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Charvier","sequence":"additional","affiliation":[{"name":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C. 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