{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:42:15Z","timestamp":1747186935856,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>First\u2010line treatment for patients with neurogenic detrusor overactivity (NDO) is anticholinergic or beta\u20103 agonist medication. The addition of a secondary medication in patients with NDO may avoid progression to third\u2010 and fourth\u2010line therapies. We aim to identify patterns of medication use for patients with neurogenic lower urinary tract dysfunction (NLUTD) using a national database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Ambulatory Medical Care Survey (NAMCS) database was queried for a sample of ambulatory patient visits from 2003 to 2015. Outpatient visits were included for all patients aged 18\u2009years or older diagnosed with NLUTD. Dual therapy was defined as prescription of two anticholinergics or one anticholinergic + beta\u20103 agonist on the same visit. Visits in which medications were prescribed were analyzed with descriptive statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of a weighted sample of 5\u2009391\u2009680 patient visits with a primary diagnosis of NLUTD, 1 602 705 (30%) were prescribed medical therapy. Of included patients prescribed NDO medications, the majority were white (80%), located in the Northeast (71%), and of a mean age of 51\u2009\u00b1\u20093. Of these patients, at least 93% of patients were prescribed anticholinergics, and 37% were prescribed dual therapy. Patients 65\u2009years and older were more likely to initiate a new NDO medication at their visit (43%) than patients under 65 (7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to analyze the use of medical therapy for NLUTD in a large outpatient setting. Further prospective evaluation of patient satisfaction and efficacy of both single anticholinergic medication and dual therapy is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12315","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T11:54:55Z","timestamp":1587729295000},"page":"266-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Contemporary use of prescription medications for neurogenic lower urinary tract dysfunction"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6040-4152","authenticated-orcid":false,"given":"Aidan","family":"Kennedy","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Urology University of Maryland Medical Center  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana","family":"Christie","sequence":"additional","affiliation":[{"name":"Division of Urology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rena D.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology University of Maryland Medical Center  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-2042","authenticated-orcid":false,"given":"Philippe E.","family":"Zimmern","sequence":"additional","affiliation":[{"name":"Division of Urology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Neurogenic Bladder \u2010 Genitourinary Disorders. 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