{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:40Z","timestamp":1772160760272,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate safety and efficacy of trigone\u2010involved Botox injections in comparison with trigone\u2010sparing injections in refractory idiopathic overactive bladder (OAB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>One hundred and three patients randomly received a 100\u2010IU intradetrusal injection of Botox either sparing the trigone (52 patients) or involving the trigone (51 patients). Patients were prospectively evaluated at 1, 3, and 6\u2009months. Efficacy was evaluated by 3\u2010day voiding diaries, OAB symptom score (OABSS), and pressure flow study. Any complications were recorded. An ascending cystogram was done at 3 months for detection of vesicoureteral reflux. Urinary tract infection (UTI) was estimated on urine culture basis. Primary outcome was the difference of total OABSS at 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age\u2009\u00b1\u2009SD was 34.3\u2009\u00b1\u200910\u2009years (range 18\u201059\u2009years). There was a reduction of episodes of all components of OAB in both groups in comparison with baseline by the end of the study but without significant difference between both groups. The trigonal\u2010sparing group had less score of frequency compared with the trigonal\u2010involved group throughout the study period (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.05). There was no difference in OABSS at 3 months (1.5\u2009\u00b1\u20090.4 vs 1.6\u2009\u00b1\u20090.3,\n                      <jats:italic>P<\/jats:italic>\n                      .875). Two patients in the trigonal\u2010involved group out of 51 (3.9%) were in need of clean intermittent catheterization because of voiding difficulty and a postvoid residual\u2009&gt;\u2009200\u2009mL. There was a higher rate of UTI in the trigonal\u2010involved group ranging from 5.6% up to 11.7% at each follow\u2010up visit. No patient had reflux.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Trigone injections are not superior to trigone\u2010sparing injections. On the contrary, the incidence of UTI and voiding difficulty were higher. The concept of reflux induced by trigonal injection has not been proven.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.12321","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T03:44:08Z","timestamp":1592279048000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Trigonal\u2010sparing versus trigonal\u2010involved Botox injection for treatment of idiopathic overactive bladder: A randomized clinical trial"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-1916","authenticated-orcid":false,"given":"Ahmed S.","family":"El\u2010Hefnawy","sequence":"first","affiliation":[{"name":"Urology Department, Mansoura Urology and Nephrology Center, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Elbaset","sequence":"additional","affiliation":[{"name":"Urology Department, Mansoura Urology and Nephrology Center, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diaa\u2010Eldin","family":"Taha","sequence":"additional","affiliation":[{"name":"Urology Department Kafr El Sheikh University  Kafr El Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem S.","family":"Wadie","sequence":"additional","affiliation":[{"name":"Urology Department, Mansoura Urology and Nephrology Center, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Kenawy","sequence":"additional","affiliation":[{"name":"Urology Department, Mansoura Urology and Nephrology Center, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A.","family":"Shokeir","sequence":"additional","affiliation":[{"name":"Urology Department, Mansoura Urology and Nephrology Center, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E.","family":"Badry","sequence":"additional","affiliation":[{"name":"Urology Department El Menia University  El Menia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12185"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12193"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1862-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22797"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22954"},{"key":"e_1_2_10_8_1","volume-title":"Diagnosis and Treatment of Non\u2010Neurogenic Overactive Bladder (OAB) in Adults: AUA\/SUFU Guideline","author":"Gormley E"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.10.047"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.136"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22956"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.14.30"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000162035.73977.1c"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2017.1362467"},{"key":"e_1_2_10_18_1","unstructured":"RadmayrC BogaertG DoganH. 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