{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:57:38Z","timestamp":1771477058738,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004324","name":"Astellas Pharma US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the cardiovascular safety of mirabegron add\u2010on treatment to tamsulosin in male patients with residual overactive bladder symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a post hoc analysis of MATCH, the first double\u2010blind, placebo\u2010controlled study comparing mirabegron and placebo as add\u2010on therapy to tamsulosin for treatment of overactive bladder in men with lower urinary tract symptoms. The analysis focused on treatment\u2010emergent adverse events relating to the cardiovascular system or blood pressure, and changes in vital signs during 12\u2009weeks of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cardiovascular\u2010related treatment\u2010emergent adverse events were reported by 6\/566 patients, although only one serious treatment\u2010emergent adverse event was related to treatment (unstable angina in the tamsulosin\u2009+\u2009placebo group). Hypertension (two patients) and increased blood pressure (one patient) were reported in the tamsulosin\u2009+\u2009placebo group, but there were no blood pressure\u2010related treatment\u2010emergent adverse events among tamsulosin\u2009+\u2009mirabegron patients. There were no clinically meaningful changes from baseline in blood pressure, and changes in pulse rate were small (+1.2\u2009bpm in the tamsulosin\u2009+\u2009mirabegron group). Increased pulse rate was more frequent with tamsulosin\u2009+\u2009mirabegron than with tamsulosin\u2009+\u2009placebo in older patients, although within the normal range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiovascular\u2010related adverse events were uncommon in both treatment groups. Mirabegron is a well\u2010tolerated add\u2010on therapy to tamsulosin in Japanese and Korean males with residual overactive bladder symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12339","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T08:29:40Z","timestamp":1601022580000},"page":"98-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular safety of mirabegron add\u2010on therapy to tamsulosin for the treatment of overactive bladder in men with lower urinary tract symptoms: A post hoc analysis from the <scp>MATCH<\/scp> study"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-4038","authenticated-orcid":false,"given":"Takao","family":"Katoh","sequence":"first","affiliation":[{"name":"Clinic at Tobu Railway Co Ltd  Tokyo 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