{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:32:37Z","timestamp":1759336357321,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Problem bladder pain syndrome\/interstitial cystitis (BPS\/IC) is a heterogeneous disorder with variation in management worldwide. Phenotyping aims to personalize therapy and optimize outcomes. The most well\u2010described phenotype is Hunner lesion disease (HLD). The prevalence of HLD and outcome of phenotype\u2010directed management in the UK is not well\u2010studied. We describe the management of a contemporary cohort of patients with BPS\/IC in the UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of all patients with BPS\/IC from January 2015\u2010November 2018. Outcomes of patients who underwent laser ablation to Hunner lesions were collected using the Global Response Assessment tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixty\u2010three patients (mean age of 43\u2009years [20\u201385]) were included. 78% were female and patients had experienced symptoms for an average 6\u2009years (1\u201330) prior to specialist assessment. Eighty\u2010three percent of patients had pelvic imaging (44% ultrasound, 42% magnetic resonance imaging and 14% computed tomography), and a relevant abnormality was found in five (4%). Twenty\u2010two patients (14%) had HLD (International Society for the Study of BPS [ESSIC] 3), with a mean bladder capacity of 373\u2009mL (175\u2010650\u2009mL); 77% were ESSIC C on histopathology. All patients with HLD underwent laser ablation, with 55% experiencing a moderate\/marked improvement in symptoms, with a mean duration of effect of 10 months (3\u201336); 27% of patients had a repeat treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of HLD in patients with BPS\/IC is not uncommon. Pelvic imaging rarely identifies any cause for pain and so cystoscopy under anesthesia is essential for accurate phenotyping. Phenotype\u2010directed management with holmium laser ablation to Hunner lesions has good short\u2010term efficacy in improving pain, but re\u2010intervention is often required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12343","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T04:54:16Z","timestamp":1598936056000},"page":"123-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bladder pain syndrome\/interstitial cystitis in contemporary UK practice: Outcomes of phenotype\u2010directed management"],"prefix":"10.1111","volume":"13","author":[{"given":"Anoushka","family":"Neale","sequence":"first","affiliation":[{"name":"Department of Urology Guy's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabiah","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Urology Guy's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Urology Guy's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Sahai","sequence":"additional","affiliation":[{"name":"Department of Urology Guy's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-9460","authenticated-orcid":false,"given":"Sachin","family":"Malde","sequence":"additional","affiliation":[{"name":"Department of Urology Guy's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2016.08.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67376-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-3293-6_4"},{"key":"e_1_2_8_5_1","unstructured":"Interstitial Cystitis Association.Interstitial Cystitis Association: Home.https:\/\/www.ichelp.org. 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