{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:31:49Z","timestamp":1792006309975,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the durability of Macroplastique\u00ae (MPQ) volume and configuration in women with stress urinary incontinence (SUI) secondary to intrinsic sphincter deficiency (ISD) using serial three\u2010dimensional ultrasound (3DUS) measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following Institutional Review Board approval, charts of women with SUI and ISD (defined based on leak point pressure; lateral imaging of urethral support without hypermobility) who underwent MPQ were reviewed from a prospectively maintained database. All had at least two serial transperineal 3DUS measurements with no MPQ or other bulking agent injection between measurements. 3DUS was performed using the Philips IU22 ultrasound system with endovaginal 3D 9\u20103V end\u2010fire probe typically at 6\u20118\u2009weeks post\u2010injection and yearly thereafter. The same imaging team blinded to clinical outcomes evaluated volume and configuration (circumferential\/symmetric or asymmetric) at each 3DUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2011 and 2019, 62 of 174 women met study criteria. Those with prior other bulking agent injection or having \u22641 3DUS follow\u2010up were excluded. Seventy\u2010one percent of patients had one injection, while the remainder had two or more (29%). Median time between first and second 3DUS was 12\u2009months. The mean change in MPQ volume between the first and last 3DUS measurement was \u22120.2\u00a0cc (95% CI: \u22120.5 to 0.004; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.054). A median of 5.0\u00a0cc were injected in each patient. Forty\u2010seven women had symmetric MPQ at first 3DUS, of whom only five (11%) had a follow\u2010up 3DUS showing asymmetric MPQ distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At mid\u2010term follow\u2010up, repeat transperineal 3DUS after MPQ injection revealed minimal change in volume and configuration in the urethral wall.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12372","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T05:31:53Z","timestamp":1608787913000},"page":"335-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Durability of Macroplastique volume and configuration in women with stress urinary incontinence secondary to intrinsic sphincter deficiency: A retrospective review"],"prefix":"10.1111","volume":"13","author":[{"given":"Timothy F.","family":"Carroll","sequence":"first","affiliation":[{"name":"Department of Urology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana","family":"Christie","sequence":"additional","affiliation":[{"name":"Simmons Comprehensive Cancer Center, Biostatistics University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Foreman","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kuprasertkul","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center  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