{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:42:06Z","timestamp":1787679726507,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether adding an anticholinergic or beta\u20103 agonist can improve the therapeutic effect of intravesical onabotuliumtoxinA injection in patients with refractory overactive bladder (OAB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety OAB patients who received an intravesical 100\u2010U onabotulinumtoxinA injection 1\u2009month previously were consecutively invited into a prospective, randomized, open\u2010label study. They were randomly adding on solifenacin 5\u2009mg daily (QD) (30 patients), mirabegron 50\u2009mg QD (31 patients), or no medication (29 patients, control). All enrolled patients completed a 3\u2010day voiding diary, Overactive Bladder Symptom Score (OABSS) and Urgency Severity Scale (USS) questionnaires, Global Response Assessment (GRA) scale, and uroflowmetry at baseline (1\u2009month after intravesical onabotulinumtoxinA injection) and 3\u2010, 6\u2010, 9\u2010, and 12\u2010month follow\u2010up. The primary end point was the effective therapeutic outcome defined as no OAB wet during the 12\u2010month period. The secondary end point included changes of GRA, OABSS, and the parameters of the voiding diary at 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline data were comparable among the three groups. The percentage of OAB wet in the mirabegron\u2010added\u2010on group was significantly less than that in the solifenacin\u2010added\u2010on and onabotulinumtoxinA\u2010only groups at four different time points (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). At 3\u2009months, the changes of GRA, OABSS, USS, urge urinary incontinence, frequency, nocturia episodes, and functional bladder capacity in the mirabegron\u2010added\u2010on group were significantly greater than those in the other groups. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adding mirabegron could increase the therapeutic effects, mainly on OAB symptoms and GRA scale, after intravesical onabotulinumtoxinA injection in refractory OAB patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12384","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T12:41:23Z","timestamp":1620477683000},"page":"440-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adding mirabegron after intravesical <scp>onabotulinumtoxinA<\/scp> injection improves therapeutic effects in patients with refractory overactive bladder"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-4011","authenticated-orcid":false,"given":"Chung\u2010Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, En Chu Kong Hospital, College of Medicine National Taiwan University  New Taipei City Taiwan"},{"name":"Department of Biomedical Engineering Chung Yuan Christian University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-2895","authenticated-orcid":false,"given":"Cheng\u2010Ling","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation, and Buddhist Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ting","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Statistics National Taipei University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of 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