{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:39:13Z","timestamp":1781559553787,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluated the efficacy of standard urotherapy and combination therapies in treatment of bladder dysfunction in children with treated behavioral disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study of children (6\u201016\u2009years) with bladder dysfunction and behavioral disorders was conducted between March 2018\u20102020. Eligible children were initially offered standard urotherapy and those with no response at 3\u00a0months were offered combination therapies. Symptomatic response, changes in Akbal score and PinQ score were reported at 6\u00a0months and outcomes were correlated to behavioral diagnoses and medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine consecutive children (male\u00a0=\u00a027, mean age [SD] 10.3 [\u00b12.0] years) were recruited, of whom 29 completed the study (five lost to follow\u2010up, three non\u2010compliant to treatment, two excluded). Thirty\u2010four (87%) children had attention deficit\/hyperactivity disorder. Monosymptomatic nocturnal enuresis (n\u00a0=\u00a011) and non\u2010monosymptomatic enuresis (n\u00a0=\u00a017) were the commonest diagnoses. Following 3\u2010month review, 14 (38%) children continued to receive standard urotherapy, while 15 (41%) children were transitioned to combination therapy. At 6\u2010month review, complete\/partial response was seen in 62% (23\/37) and no response in 16% (6\/37); with 32% (12\/37) responding to standard urotherapy alone. Akbal symptom scores (15.9\u201011.5; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.01) and PinQ scores (26.0\u201019.5; <jats:italic>P<\/jats:italic>\u00a0=\u20090.008) improved significantly at 6\u2010month follow\u2010up. Type of underlying behavioral disorder(s) or medications for behavioral disorder did not influence the outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms that children with underlying behavioral disorders are able to have a good response to the appropriate therapy for their bladder dysfunction with a third of children responding to standard urotherapy alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12400","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T11:19:53Z","timestamp":1627384793000},"page":"490-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of standard urotherapy (basic bladder advice) and combination therapies in managing bladder dysfunction in children with treated behavioral disorders: Results of a prospective cohort (DABBED) study"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2573-1224","authenticated-orcid":false,"given":"Dilharan D.","family":"Eliezer","sequence":"first","affiliation":[{"name":"John Hunter Children\u02bcs Hospital  New Lambton Heights New South Wales Australia"},{"name":"University of Newcastle  Callaghan New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem","family":"Samnakay","sequence":"additional","affiliation":[{"name":"Department of Surgery Perth Children\u02bcs Hospital  Perth Western Australia Australia"},{"name":"Division of Surgery Medical School, University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm R.","family":"Starkey","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute  New Lambton Heights New South Wales Australia"},{"name":"Department of Immunology and Pathology Central Clinical School, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniruddh V.","family":"Deshpande","sequence":"additional","affiliation":[{"name":"John Hunter Children\u02bcs Hospital  New Lambton Heights New South Wales Australia"},{"name":"University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute  New Lambton Heights New South Wales Australia"},{"name":"Urology Unit, Department of Surgery The Children\u02bcs Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Centre for Kidney Research The Children\u02bcs Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-014-0577-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-3040-z"},{"issue":"8","key":"e_1_2_10_4_1","first-page":"763","article-title":"Specific behavioral comorbidity in a large sample of children with functional incontinence: report of 1,001 cases","volume":"34","author":"Gontard A","year":"2015","journal-title":"NeurourolUrodyn"},{"issue":"5","key":"e_1_2_10_5_1","first-page":"264","article-title":"Incontinence in children with autism spectrum disorder","volume":"11","author":"Gontard A","year":"2015","journal-title":"J Pediatr 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