{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:52:07Z","timestamp":1775872327350,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX201820"],"award-info":[{"award-number":["ZYLX201820"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801429"],"award-info":[{"award-number":["81801429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This meta\u2010analysis aimed to assess the efficacy and safety of mirabegron in treating ureteral stent\u2010related symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched to identify randomized controlled trials (RCT) of mirabegron in treating ureteral stent\u2010related symptoms. We conducted a systematic review and meta\u2010analysis based on the eligible RCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five RCT including 546 patients and comparing mirabegron with placebo or blank control were involved in the present research. Regarding efficacy, mirabegron was superior to controls in urinary symptom score (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0006) and general health score (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) of the Ureteral Stent Symptom Questionnaire, total International Prostate Symptom Score (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.00001), quality of life (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), analgesic use (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008), and readmission or visit to hospital due to discomfort (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Safety assessments including adverse events (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.40) suggested that mirabegron was well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present meta\u2010analysis shows that mirabegron is an effective and safe treatment for relieving ureteral stent\u2010related symptoms with a low occurrence of adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12405","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T06:09:51Z","timestamp":1628316591000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The efficacy and safety of mirabegron in treating ureteral stent\u2010related symptoms: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3310-4220","authenticated-orcid":false,"given":"Zhouyue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-449X","authenticated-orcid":false,"given":"Yuanshan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Department of Urology Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-6115","authenticated-orcid":false,"given":"Yumeng","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)63130-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)57326-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000048980.33855.90"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000049198.53424.1d"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.05.091"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-019-2096-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-013-0554-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2016.0129"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0509-9"},{"key":"e_1_2_11_11_1","volume-title":"EAU Guidelines on Urinary Incontinence in Adults","author":"Burkhard FC","year":"2020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000309"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.10.016"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14416"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12320"},{"issue":"1","key":"e_1_2_11_17_1","first-page":"54","article-title":"Treatment of ureteral catheter related symptoms; 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