{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:53:20Z","timestamp":1768283600443,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Diagnosis of Hunner\u2010type interstitial cystitis (HIC) relies on the ability to identify Hunner lesions endoscopically, which can lead to storage symptom misdiagnosis. Here, we examined serum biomarkers for HIC and verified their utility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the previous definition of the Japanese guidelines, which did not distinguish HIC and non\u2010HIC diseases, we searched for serum biomarkers in 25 patients with interstitial cystitis (IC) and 25 control participants using metabolomics during 2013\u20132014. In 2019, we conducted a validation study in HIC and control groups. Serum samples were analyzed using liquid chromatography\u2013tandem mass spectrometry, and candidate biomarker concentrations were compared between the groups using Mann\u2013Whitney test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Metabolomics targeted 678 metabolites and revealed that the levels of 14 lysolipids, seven \u03b3\u2010glutamyl amino acids, and two monoacylglycerols were significantly different between the IC and control groups. The following metabolites were selected from each metabolite category as candidates: 1\u2010linoleoylglycerophosphocholine (1\u2010linoleloyl\u2010GPC [18:2]), \u03b3\u2010glutamylisoleucine (\u03b3\u2010Glu\u2010Ile), and 1\u2010arachidonylglycerol (1\u2010AG). The serum concentrations of 1\u2010linoleoyl\u2010GPC (18:2) in the HIC and control groups were 27\u2009920\u2009\u00b1\u20096261 and 40\u2009360\u2009\u00b1\u20091514\u2009ng\/mL (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0003), respectively. The serum concentrations of \u03b3\u2010Glu\u2010Ile and 1\u2010AG were not significantly different between the groups. When the cut\u2010off value of 1\u2010linoleoyl\u2010GPC (18:2) was set at 28\u2009400\u2009ng\/mL, the sensitivity and specificity were 68% and 84%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum 1\u2010linoleoyl\u2010GPC (18:2) is a candidate diagnostic biomarker for HIC. Additional studies on whether this biomarker can distinguish HIC from other diseases with high urination frequency are required for its clinical use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12439","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T05:38:27Z","timestamp":1647841107000},"page":"334-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of diagnostic serum biomarkers for Hunner\u2010type interstitial cystitis"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-0466","authenticated-orcid":false,"given":"Kazumasa","family":"Torimoto","sequence":"first","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Ueda Clinic  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Science Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihide","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Nara Hospital  Ikoma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Urology Saiseikai Chuwa Hospital  Sakurai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hoshigaoka Medical Center  Hirakata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-3820","authenticated-orcid":false,"given":"Daisuke","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makito","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohide","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14234"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.2142084.042"},{"key":"e_1_2_11_4_1","first-page":"486","article-title":"A survey on clinical practice of interstitial cystitis in Japan","volume":"4","author":"Yamada Y","year":"2015","journal-title":"Transl Androl 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