{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:51:03Z","timestamp":1773780663181,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether more severe urinary symptoms and poorer quality of life among patients on diuretic therapy are associated with decreased adherence to the diuretic regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were recruited via <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/researchmatch.org\">ResearchMatch.org<\/jats:ext-link> and sent a REDCap survey. The Overactive Bladder Questionnaire\u2010Short Form (OAB\u2010q SF) was used to assess urinary symptom bother and health\u2010related quality of life (HRQL). Participants were asked if they skip diuretic doses due to urinary symptoms with a bivariate (yes or no) outcome. Subgroup analyses of loop vs non\u2010loop diuretic and those taking the diuretic for a cardiovascular indication (hypertension or heart failure) were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4029 surveys were sent, 285 were returned (7.1% response rate), and 279 were included in the study. Fifty\u2010three participants admitted to skipping diuretic doses due to urinary symptoms. Lower HRQL scores were significantly associated with poorer adherence scores among all participants (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), among participants taking a loop diuretic (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and among participants with hypertension and heart failure (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.039). Association between symptoms and adherence remained significant after adjustment in the multivariate model for the whole cohort and loop diuretic subgroup but lost significance in the hypertension and heart failure subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Worsening quality of life due to urinary symptoms may be associated with poorer adherence to diuretics, particularly loop diuretics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12452","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T06:34:45Z","timestamp":1656052485000},"page":"366-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of lower urinary tract symptoms and diuretic adherence"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5410-5612","authenticated-orcid":false,"given":"Matthew L.","family":"Miller","sequence":"first","affiliation":[{"name":"University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3867-070X","authenticated-orcid":false,"given":"Brent N.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Maryland School of Pharmacy  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-6764","authenticated-orcid":false,"given":"Rena D.","family":"Malik","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016370925601"},{"key":"e_1_2_8_3_1","unstructured":"International Continence Society [Internet]. Bristol: International Continence Society; c2020 [cited 2020 Apr 25]. ICS Glossary; [about 73 screens]. 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Metrics; [about 2 screens]. Available from:https:\/\/www.researchmatch.org\/metrics\/"},{"key":"e_1_2_8_21_1","unstructured":"Pfizer Patient\u2010Centered Outcomes Assessment [Internet]. New York: Pfizer; c2019 [cited 2020 Apr 1]. Overactive Bladder Questionnaire (OAB\u2010Q SF 4\u2010Week Recall); [about 2 screens]. Available from:https:\/\/www.pfizerpcoa.com\/overactive\u2010bladder\u2010questionnaire\u2010oab\u2010q\u2010sf\u20104\u2010week\u2010recall"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22559"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098\u20103015(10)67167\u20107"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200837"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/02664769823304"},{"key":"e_1_2_8_26_1","unstructured":"ThakeM Al\u2010MohammadA GibsonW.What is known about lower urinary tract symptoms (LUTS) in heart failure? A scoping review. In: ICS 2020 Online; November 19\u201322 2020; Las Vegas Nevada. Abstract 57."}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/luts.12452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T08:15:09Z","timestamp":1692778509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/luts.12452"],"URL":"https:\/\/doi.org\/10.1111\/luts.12452","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]},"assertion":[{"value":"2022-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}