{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:46:57Z","timestamp":1785354417771,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To clarify Japanese real\u2010world clinical data on the use of desmopressin 25 and 50\u2009\u03bcg orally disintegrating tablets (ODT) for male patients with nocturia and evaluate the predictive factors to improve nighttime frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively accumulated real\u2010world clinical data from 27 institutions in Japan. Male patients with two or more episodes of nocturia who received desmopressin ODT for nocturnal polyuria (NP) from 2019 through 2021 were included. The primary endpoint was the change of nighttime frequency until 3\u2009months after desmopressin administration. The secondary endpoints were to clarify the persistence rate, adverse events, and predictive factors of decreasing nighttime frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 118 patients were eligible to participate in this study. The persistence rate of desmopressin on the Kaplan\u2010Meier curve at week 12 was 51.3. The reason for discontinuation was mainly the occurrence of adverse events in 67 patients (56.8%), particularly hyponatremia in 7 patients (5.9%). Nighttime frequencies at baseline, \u2010 1\u2009month and 1\u00a0\u2010\u00a03\u2009months after desmopressin administration were 4.1\u2009\u00b1\u20091.3, 2.9\u2009\u00b1\u20091.4 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), and 2.6\u2009\u00b1\u20091.3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), respectively. The mean nighttime urine volume voided at baseline was significantly larger in patients whose nighttime frequency decreased by two or more times than in those with a decrease of less than two times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Desmopressin 25 and 50\u2009\u03bcg ODT treatments are feasible for male patients with NP in Japanese real\u2010world clinical practice. Patients with higher voided volumes, particularly in the nighttime, may have great benefit from desmopressin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12459","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T04:13:01Z","timestamp":1659759181000},"page":"410-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of desmopressin orally disintegrating tablets 25 and 50\u2009\u03bcg in male patients with nocturia: A Japanese real\u2010world multicenter clinical study"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-5051","authenticated-orcid":false,"given":"Yuki","family":"Kyoda","sequence":"first","affiliation":[{"name":"Department of Urology Sapporo Medical University School of Medicine  Sapporo Japan"},{"name":"Nemuro City Hospital  Nemuro Japan"},{"name":"Yakumo General Hospital  Yakumo Japan"},{"name":"Hokkaido 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