{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:21:11Z","timestamp":1766600471351,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002679","name":"Adnan Menderes \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To reveal the histopathological and immunological outcomes of intravesical treatment with tarantula cubensis extract (TCE) in a rat model of interstitial cystitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 30 female Wistar albino rats were divided into three groups: group 1 (control group), group 2 (disease group), and group 3 (treatment group). The rat model of interstitial cystitis was created by biweekly intraperitoneal administration of cyclophosphamide (CYP). In group 3, TCE (a venom extracted from a brown spider known as tarantula cubensis) was administered intravesically after the model had been created. Urothelial degeneration, necrosis, ulcer, bleeding, edema, inflammation and mast cell count, interleukin\u20106 (IL\u20106), tumor necrosis factor\u2010alpha (TNF\u2010alpha), myeloperoxidase (MPO), and hydroxyproline parameters were evaluated. Statistical analysis was performed using one\u2010way analysis of variance, chi\u2010square tests, and Kruskal\u2013Wallis tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All parameters were found to be lower in the rats in group 1 than in the other groups, and IL\u20106 and MPO values were found to be higher in group 2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The mean TNF\u2010alpha value was highest in group 2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.078). No difference was found between all groups regarding ulcer (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.087). Urothelial degeneration, necrosis, edema, inflammation, hemorrhage and fibroblast proliferations, and hydroxyproline values were higher in group 3 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravesical TCE instillation produces an anti\u2010inflammatory effect by reducing the levels of inflammatory parameters such as IL\u20106, TNF\u2010alpha, and MPO in bladder tissue. It also accelerates tissue healing by increasing hydroxyproline and fibroblast proliferation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12470","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T19:23:10Z","timestamp":1670440990000},"page":"63-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of intravesical tarantula cubensis extract (Theranekron) on inflammation in an interstitial cystitis rat model"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-0913","authenticated-orcid":false,"given":"Abdullah","family":"Akda\u011f","sequence":"first","affiliation":[{"name":"Department of Urology S\u00f6ke Fehime Faik Kocag\u00f6z State Hospital  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7i\u011fdem","family":"Yenisey","sequence":"additional","affiliation":[{"name":"Department of Medical 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