{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:08:38Z","timestamp":1780585718958,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to compare the efficacy of the transobturator tape (TOT) procedure combined with solifenacin (TOT\u2010S) or prasterone (TOT\u2010P) in postmenopausal women affected by mixed urinary incontinence (MUI) with a predominant stress urinary incontinence component.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective analysis including 112 patients: 60 patients of the TOT\u2010S group and 52 patients of the TOT\u2010P group. Physical examination, 3\u2010day voiding diary, urodynamic tests, and Vaginal Health Index (VHI) were compared at the beginning of the analysis and after 12\u2009weeks of follow\u2010up (FU). Specific questionnaires were administered to indagate the impact on women's quality of life and sexual function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12\u2009weeks of FU, the detrusor's peak flow pressure was significantly different between the two groups (<jats:italic>p<\/jats:italic>\u00a0=\u2009.02). Detrusor overactivity decreased only in the TOT\u2010P group (<jats:italic>p<\/jats:italic>\u00a0=\u2009.05). At the end of FU, 58 patients (96.7%) of the TOT\u2010S group and 50 patients (96.2%) of the TOT\u2010P group were dry at the stress test. A significative group difference was observed in urge urinary incontinence (24\u2009h) (<jats:italic>p<\/jats:italic>\u00a0=\u2009.01) but not in the mean number of voids (24\u2009h) and urgent micturition events (24\u2009h). VHI improved only in the TOT\u2010P group (12.57\u2009\u00b1\u20093.80 vs. 19.75\u2009\u00b1\u20094.13, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.0001). The questionnaires and Patient Global Index of Improvement (PGI\u2010I) scores showed comparable improvements, while the Female Sexual Function Index improved especially in the TOT\u2010P group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In postmenopausal women with MUI, TOT\u2010P demonstrated the same effectiveness as TOT\u2010S in reducing urinary symptoms. In addition, TOT\u2010P increased VHI and sexual function scores compared with TOT\u2010S.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12476","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T10:14:54Z","timestamp":1677924894000},"page":"96-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["TOT in combination with solifenacin or intravaginal prasterone in postmenopausal women with mixed urinary incontinence: A retrospective analysis in 112 patients"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3273-6410","authenticated-orcid":false,"given":"Federica","family":"Sala","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Section of Gynecology and Obstetrics University Tor Vergata  Rome Italy"},{"name":"Department of Gynecological and Obstetrics Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5141-5957","authenticated-orcid":false,"given":"Melania","family":"Loggia","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Gynecology and Obstetrics University Tor Vergata  Rome Italy"},{"name":"Department of Gynecological and Obstetrics Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-6466","authenticated-orcid":false,"given":"Giorgia","family":"Cardella","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Gynecology and Obstetrics University Tor Vergata  Rome Italy"},{"name":"Department of Gynecological and Obstetrics Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-6071","authenticated-orcid":false,"given":"Claudia","family":"Morgani","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Gynecology and Obstetrics University Tor Vergata  Rome Italy"},{"name":"Department of Gynecological and Obstetrics Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6753-5921","authenticated-orcid":false,"given":"Giovanni","family":"Grossi","sequence":"additional","affiliation":[{"name":"Department of Gynecological and Obstetrics Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-0210","authenticated-orcid":false,"given":"Marzio Angelo","family":"Zullo","sequence":"additional","affiliation":[{"name":"Department of Week\u2010Surgery, Campus Biomedico University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-544X","authenticated-orcid":false,"given":"Herbert Carmelo Carlo","family":"Valensise","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Gynecology and Obstetrics University Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4397-648X","authenticated-orcid":false,"given":"Pier Luigi","family":"Palazzetti","sequence":"additional","affiliation":[{"name":"Department of Gynecological and Obstetrics Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-170X","authenticated-orcid":false,"given":"Michele Carlo","family":"Schiavi","sequence":"additional","affiliation":[{"name":"Department of Gynecological and Obstetrics Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0976-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1024\/0040\u20105930\/a001038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-002-0301-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.42"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001405.pub3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.06.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000002007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00451721"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20674"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11006.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-1069-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(95)00956-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-014-2461-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21036"},{"key":"e_1_2_7_16_1","first-page":"212","article-title":"New surgical technique for treatment of stress urinary incontinence TVT\u2010obturator: new developments and results","volume":"14","author":"Leval J","year":"2005","journal-title":"Surg Technol Int"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6777(2000)19:5<553::AID-NAU2>3.0.CO;2-B"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677\u20105538.IBJU.2019.0331"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(93)90028-G"},{"key":"e_1_2_7_20_1","unstructured":"European Medicines Agency.Intrarosa: summary of product characteristics.2019.http:\/\/www.ema.europa.eu\/Accessed 20 June 2019."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001177"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.09.017"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd001407"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006375.pub4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724\u2010606X.22.05106\u20105"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192\u2010017\u20103417\u20101"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13541"},{"key":"e_1_2_7_28_1","first-page":"32","article-title":"Female pelvic conditions: genitourinary syndrome of menopause","volume":"515","author":"Brady PH","year":"2022","journal-title":"FP Essent"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1500534"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1441398"},{"issue":"3","key":"e_1_2_7_31_1","first-page":"231","article-title":"Treating anterior vaginal wall prolapse with polypropylene mesh via the transoburator route minimizing the complications with the use of preventing measures. A prospective study with 2\u2010year follow\u2010up","volume":"67","author":"Adamakis I","year":"2015","journal-title":"Minerva Ginecol"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/luts.12476","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:32:25Z","timestamp":1692729145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,4]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/luts.12476"],"URL":"https:\/\/doi.org\/10.1111\/luts.12476","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,4]]},"assertion":[{"value":"2022-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}