{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:50:27Z","timestamp":1768405827584,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007404","name":"Clinical Trial Center, China Medical University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007404","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study investigates the efficacy and adverse events of beta\u20103 agonists and antimuscarinic agents for managing overactive bladder syndrome in Sjogren syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sjogren's syndrome patients with an Overactive Bladder Symptom Score (OABSS) &gt;5 were enrolled and were randomly assigned to mirabegron 50\u2009mg\/day or solifenacin 5\u2009mg\/day. Patients were evaluated on the recruitment day and reassessed at Week 1, 2, 4, and 12. The study's primary endpoint was to have a significant change in OABSS at Week 12. The secondary endpoint was the adverse event and crossover rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 41 patients were included in the final analysis, with 24 in the mirabegron group and 17 in the solifenacin group. The study's primary outcome was a change of the OABSS at Week 12. We found that both mirabegron and solifenacin significantly reduce patients' OABSS after 12\u2009weeks of treatment. The evolution of the OABSS was \u22123.08 for mirabegron and \u22123.71 for solifenacin (<jats:italic>p<\/jats:italic>\u2009=\u2009.56). Six out of 17 patients from the solifenacin group crossed over to the mirabegron arm due to severe dry mouth or constipation, while none from the mirabegron arm crossed over to the solifenacin group. Sjogren's syndrome\u2010related pain was also improved in the mirabegron group (4.96\u20131.67, <jats:italic>p<\/jats:italic>\u2009=\u2009.008) compared to the solifenacin group (4.39\u20133.4, <jats:italic>p<\/jats:italic>\u2009=\u2009.49).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed that mirabegron is equally effective as solifenacin in treating Sjogren's syndrome patients with overactive bladder. Mirabegron is superior to solifenacin in terms of treatment\u2010related adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12481","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T10:54:36Z","timestamp":1684234476000},"page":"139-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mirabegron is better tolerated than solifenacin in Sjogren's syndrome patients with overactive bladder symptoms\u2014A randomized controlled trial"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-1570","authenticated-orcid":false,"given":"Hao Xiang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology China Medical University Hospital, China Medical University  Taichung 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