{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:02Z","timestamp":1753879262570,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the relationship between the 2nd and 4th digit ratios, which are associated with fetal androgen exposure, and prostate volume and testosterone levels, both of which are linked to lower urinary tract symptoms (LUTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male patients presenting to our urology clinic with increased prostate volume and LUTS were categorized into two groups: those with BPH and those without (non\u2010BPH). For both groups, the right\u2010hand 2D:4D finger ratio, testosterone levels, prostate volume, uroflow parameters, and IPSS scores were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 2D:4D ratio, prostate volumes, Qmax, and IPSS scores differed significantly between the BPH and non\u2010BPH groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.023, 0.002, 0.000, 0.001). No significant difference was observed in total testosterone levels between the groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.381). The 2D:4D ratio was negatively correlated with prostate volume and IPSS (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.389, \u22120.308) and positively correlated with Qmax (<jats:italic>r<\/jats:italic>\u2009=\u20090.301).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates that the 2D:4D ratio is a straightforward and effective tool for assessing BPH patients, as it correlates with the severity of LUTS symptoms. This non\u2010invasive measure offers potential value in evaluating LUTS, and with age standardization, it could be applied more broadly across age groups. Further large\u2010scale studies are needed to refine its standardization and expand upon current findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.70009","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T04:05:46Z","timestamp":1740024346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Digit Length Ratio as an Indicator of Fetal Androgen Levels: Relationship to Prostate Volume\u2010Related Men Lower Urinary Tract Symptoms"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-0533","authenticated-orcid":false,"given":"\u0130smail Emre","family":"Ergin","sequence":"first","affiliation":[{"name":"Department of Urology Etlik City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6090-6133","authenticated-orcid":false,"given":"Abuzer","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Clinic of Urology Sivas Numune Hospital  Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-6727","authenticated-orcid":false,"given":"Aydemir","family":"Asdemir","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1016\/S0140-6736(03)13073-5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1016\/j.ucl.2016.04.001"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1016\/j.ucl.2011.09.005"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1002\/(SICI)1097-0045(19970501)31:2<131::AID-PROS9>3.0.CO;2-Q"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1289\/ehp.1307178"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1172\/JCI34241"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1530\/rep.1.00025"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1038\/onc.2008.327"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1097\/01.ju.0000133655.71782.14"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1016\/j.urology.2007.05.025"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1210\/jc.2012-4057"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1016\/j.juro.2011.10.041"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1002\/ajhb.21054"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1016\/j.earlhumdev.2003.12.002"},{"issue":"12","key":"e_1_2_10_16_1","article-title":"2D: 4D Ratio and Its Implications in Medicine","volume":"10","author":"Jeevanandam S.","year":"2016","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1016\/j.yhbeh.2011.05.009"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1038\/aja.2011.75"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1111\/j.2047-2927.2014.00256.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1016\/j.sxmr.2018.10.006"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1111\/and.13589"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1007\/s00345-020-03511-6"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1111\/andr.12318"},{"issue":"5","key":"e_1_2_10_24_1","article-title":"Relationship Between Second to Fourth Digit Ratios and Benign Prostatic Hyperplasia in Aging Men","volume":"9","author":"Sudhakar H. 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