{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:34:29Z","timestamp":1770888869606,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This retrospective study aimed to compare the surgical outcomes of holmium laser enucleation of the prostate (HoLEP) and transurethral vaporization techniques between the elderly and nonelderly patients with benign prostatic enlargement (BPE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed clinical data from two regional centers that used HoLEP and transurethral vaporization techniques for BPE treatment. The study population consisted of male patients with lower urinary tract symptoms, divided into elderly and nonelderly groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 477 of 872 patients remained in the study, of which 198 were classified as elderly (age\u2009\u2265\u200975\u2009years) and 279 as non\u2010elderly (age\u2009&lt;\u200975\u2009years). The postoperative decrease in IPSS was significantly lower in the elderly group, and advanced age was associated with less IPSS decline only after vaporization (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) but not after HoLEP. In both surgeries, the duration of postoperative catheterization was significantly longer in the elderly group than in the non\u2010elderly group, and hemoglobin drop at 1 day postoperatively showed no age\u2010related difference. The most common complication after HoLEP was intermittent incontinence, which was more frequent in the elderly group (15.0%) than in the non\u2010elderly group (6.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.038). Regardless of age, the overall rate of need for medication at 6\u2009months postoperatively was significantly higher after HoLEP (32\/190, 16.8%) than after transurethral vaporization (30\/287, 10.5%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.042). The need for medication was higher in the elderly for both HoLEP and vaporization than in the non\u2010elderly group with a specific cutoff of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elderly patients with BPE had relatively worse surgical outcomes, including a higher need for postoperative medications and prolonged catheterization. HoLEP demonstrated a reduction in IPSS regardless of age, and transurethral vaporization did not, although it was associated with a higher rate of intermittent incontinence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.70010","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T21:27:54Z","timestamp":1741382874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective Comparison of Postoperative Outcomes Between Elderly and Non\u2010Elderly Patients With Benign Prostatic Enlargement Using Holmium Laser Enucleation and Transurethral Vaporization of the Prostate at Multiple High\u2010Volume Centers"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-370X","authenticated-orcid":false,"given":"Hiroki","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"},{"name":"Department of Urology Yokosuka Kyosai Hospital  Yokosuka Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Nirei","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Fukazawa","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Hioki","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Shinoki","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Yokosuka Kyosai Hospital  Yokosuka Kanagawa Japan"},{"name":"Department of Urology International Goodwill Hospital  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuko","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Department of Urology International Goodwill Hospital  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Makiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitoshi","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Urology International Goodwill Hospital  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.04.008"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.12.002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12745"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.025"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2016.04.001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(22)00213\u20106"},{"key":"e_1_2_12_8_1","unstructured":"S.Gravas J.\u2010N.Cornu M.Gacci et\u00a0al. \u201cEAU Guidelines on Management of Non\u2010Neurogenic Male Lower Urinary Tract Symptoms (LUTS) Including Benign Prostatic Obstruction (BPO) \u201dhttp:\/\/www.uroweb.org\/guideline\/treatment\u2010of\u2010non\u2010neurogenic\u2010male\u2010luts\/2021."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.06.017"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.06.012"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.11.001"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261586"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.03.072"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010022\u201004179\u2010w"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2022.0654"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12063"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1630478.239"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cont.2022.100034"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894\u2010023\u201001215\u20108"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.03.034"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2016.04.006"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.07.019"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15260"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.04.019"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1732640.320"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677\u20105538.IBJU.2019.0411"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21050"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2007.06867.x"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000092035.16351.9d"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000280"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.3774"},{"issue":"6","key":"e_1_2_12_32_1","first-page":"501","article-title":"Effects of Aging on Inflammation and Hemostasis Through the Continuum of Critical Illness","volume":"2","author":"Kale S. S.","year":"2011","journal-title":"Aging and Disease"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14926"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.70010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T19:13:07Z","timestamp":1743275587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.70010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/luts.70010"],"URL":"https:\/\/doi.org\/10.1111\/luts.70010","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70010"}}