{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:50:24Z","timestamp":1774281024643,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Overactive bladder (OAB) is a prevalent urological condition often perceived as negligible or non\u2010threatening, leading to its potential links with severe health conditions being overlooked. Notably, the relationship between OAB and cancer remains unexplored. This study endeavors to elucidate the association of OAB with cancer prevalence and mortality risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study utilized data from the 2007 to 2016\u2009cycles of the National Health and Nutrition Examination Survey (NHANES), incorporating linked mortality data up to December 31, 2019. OAB symptoms were quantified using the modified overactive bladder symptom score (OABSS), with scores \u2265\u20093 confirming diagnosis. Cancer status was self\u2010reported and further clarified for cancer type. We employed multivariate weighted logistic regression to examine the association between OAB and cancer prevalence, and subgroup analysis to identify variations across demographic and clinical characteristics. Cumulative mortality incidence curves, adjusted via inverse probability weighting, and multivariate Cox regression analysis were utilized to investigate the relationship between OAB and cancer\u2010related mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20\u2009468 adults aged 20 and older were involved in this study. After adjusting for potential confounders, OAB was positively associated with the risk of cancer (OR\u2009=\u20091.36, 95% CI: 1.18, 1.57). Subgroup analysis revealed significant interactions between OAB and age (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u2009=\u20090.001). Survival analysis suggests that OAB was linked to higher all\u2010cause mortality risks exclusively among cancer patients (HR 1.39, 95% CI: 1.17, 1.65) and elevated cancer\u2010specific mortality across the overall population (HR 1.33, 95% CI: 1.03, 1.73).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OAB is associated with the prevalence and mortality of cancer among US adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.70018","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T01:33:32Z","timestamp":1750642412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overactive Bladder is Positively Associated With the Prevalence and Mortality of Cancer Among <scp>US<\/scp> Adults"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8394-2743","authenticated-orcid":false,"given":"Jianing","family":"Liu","sequence":"first","affiliation":[{"name":"Medical Faculty Ulm University  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical School Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-024-06029-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.038"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(24)00029-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.03.004"},{"issue":"8","key":"e_1_2_9_8_1","article-title":"Metabolic Syndrome and Overactive Bladder Syndrome May Share Common Pathophysiologies","volume":"10","author":"Hsu L. 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