{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:56:09Z","timestamp":1791899769232,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this research is to determine the effectiveness and safety of a vaginal mesh intended to resolve multicompartmental prolapse in individuals with substantial vaginal vault prolapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2015 to 2020, 67 patients with recurrent apical prolapse \u2265 III stage (POP\u2010Q grading) underwent transvaginal vault repair using the isoelastic mesh InGYNious. Operative time, blood transfusions, spontaneous voiding, perioperative issues, postoperative hospital stay, and postoperative complications (early within 30\u2009days and late after 30\u2009days) were also investigated. Following the first preoperative examination, clinical and QoL questionnaires were examined both before and after surgery at the long\u2010term follow\u2010up (&gt;\u200960\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average surgery duration was 41\u2009\u00b1\u200921\u2009min, with an estimated blood loss of 50\u2009\u00b1\u200921\u2009mL. The total number of surgical complications was eight (11.9%). The study discovered significant reductions in the apical (from 1.88\u2009\u00b1\u20092.59 to \u22126.73\u2009\u00b1\u20091.77) and anterior (from 1.34\u2009\u00b1\u20091.67 to \u22122.25\u2009\u00b1\u20090.95) deficiencies, as well as improvements in PQOL (from 67.72\u2009\u00b1\u200919.25 to 33.74\u2009\u00b1\u20097.48), PISQ\u201012 (from 29 to 36), FSFI (from 20 to 29), and FSDS (from 21 to 8). Finally, we identified three cases of full recurrence and only two occurrences needed reoperation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transvaginal mesh repair is a safe and effective surgical technique that can treat multi\u2010compartment prolapse, improve anatomical success, and reduce the risk of recurrence in certain patient populations, such as those with significant comorbidities, elderly patients, patients with recurrent POP, or patients with very challenging cases of POP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.70021","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T06:23:44Z","timestamp":1752215024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is Vaginal Prosthetic Surgery Always to Be Avoided? Analysis of the Efficacy and Safety of Vaginal Mesh With 3 Levels\u2010De Lancey Attachment in Women With Recurrent Vaginal Vault Prolapse"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3544-3190","authenticated-orcid":false,"given":"Lorenzo","family":"Campanella","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ospedale Sandro Pertini  Rome Italy"},{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 di Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Grossi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ospedale Sandro Pertini  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Passarello","family":"Alessandra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ospedale Sandro Pertini  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Cignini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ospedale Sandro Pertini  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Manganelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ospedale Sandro Pertini  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Palazzetti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ospedale Sandro Pertini  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Zullo","sequence":"additional","affiliation":[{"name":"AIUG Research Groups, Associazione Italiana di UroGinecologia e del Pavimento Pelvico  Rome Italy"},{"name":"Department of Week\u2010Surgery Policlinico Universitario Campus Bio Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Morciano","sequence":"additional","affiliation":[{"name":"AIUG Research Groups, Associazione Italiana di UroGinecologia e del Pavimento Pelvico  Rome Italy"},{"name":"Department of Obstetrics and Gynaecology Pia Fondazione Cardinale G. Panico  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Rappa","sequence":"additional","affiliation":[{"name":"AIUG Research Groups, Associazione Italiana di UroGinecologia e del Pavimento Pelvico  Rome Italy"},{"name":"Andrea Grimaldi Medical Care  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Deltetto","sequence":"additional","affiliation":[{"name":"San Luca Nursing Home  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Schiavi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ospedale Sandro Pertini  Rome Italy"},{"name":"AIUG Research Groups, Associazione Italiana di UroGinecologia e del Pavimento Pelvico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S71236"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2016.32.1.7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000175832.13266.bb"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3512-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003488"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3069-6"},{"key":"e_1_2_10_8_1","unstructured":"https:\/\/www.iss.it\/documents\/20126\/9020128\/LG_C0014_SIGO_Prolasso+organi+pelvici.pdf\/0a33787b\u20106685\u20101690\u2010412c\u20107c73b11da0a2?t=1712222592777."},{"issue":"7","key":"e_1_2_10_9_1","article-title":"Surgery for Women With Apical Vaginal Prolapse","volume":"7","author":"Maher C.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"e_1_2_10_10_1","article-title":"Transvaginal Mesh or Grafts or Native Tissue Repair for Vaginal Prolapse","volume":"3","author":"Yeung E.","year":"2024","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3493-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.101977"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-020-04515-x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14341"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.10.030"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23968"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2021.02.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05408-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.12.029"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05442-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003519"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22922"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000441"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-021-04934-4"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11039-5"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31596-3"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-3104-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-011-0798-x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4307-y"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000463"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062212"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.70021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T08:12:40Z","timestamp":1753776760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.70021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/luts.70021"],"URL":"https:\/\/doi.org\/10.1111\/luts.70021","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70021"}}