{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T03:10:06Z","timestamp":1758856206334,"version":"3.44.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Benign prostatic hyperplasia (BPH) is a common urological condition in aging men that causes lower urinary tract symptoms. Pharmacotherapy is central to BPH management; however, considering updated guidelines, recent prescription trends remain insufficiently explored. This study aimed to assess initial pharmacotherapy trends in patients newly diagnosed with BPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional analysis used 2015\u20132020 data from the Health Insurance Review and Assessment Service to examine the trends and influencing factors of BPH drug utilization among South Korean patients aged \u2265\u200940\u2009years with no prior history of BPH. Subgroup analyses were performed by categorizing patients into five age groups (40\u201349, 50\u201359, 60\u201369, 70\u201379, and \u2265\u200980\u2009years) to evaluate age\u2010specific prescription patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1,445,144 patients newly diagnosed with BPH, 1,336,695 (92.4%) initiated treatment within 60\u2009days of diagnosis. Among those treated, 54.9% received \u03b1\u2010blocker (AB) monotherapy and 17.9% received 5\u03b1\u2010reductase inhibitor (5\u2010ARI)\/AB combinations. Use of 5\u2010ARI\/AB combinations increased with age, from 8.0% in patients in their 40s to 25.4% in those aged \u2265\u200980\u2009years. Tamsulosin (a selective AB), dutasteride (a 5\u2010ARI), and mirabegron (a \u03b23\u2010agonist) were the most frequently prescribed agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recent American Urological Association (AUA) guidelines recommend combination therapy as an effective strategy for reducing the risk of BPH\u2010related complications. Although the largest proportion of patients was prescribed AB monotherapy, the growing adoption of combination therapy in South Korea, particularly among older age groups, suggests a shift toward more guideline\u2010concordant and effective therapeutic approaches.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.70030","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T08:00:08Z","timestamp":1757059208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prescription Trends of Initial Pharmacotherapy for Benign Prostatic Hyperplasia Among Treatment\u2010Na\u00efve Patients in South Korea: A Retrospective Analysis"],"prefix":"10.1111","volume":"17","author":[{"given":"Yeon Hee","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy Pusan National University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-5131","authenticated-orcid":false,"given":"Nam Kyung","family":"Je","sequence":"additional","affiliation":[{"name":"College of Pharmacy Pusan National University  Busan Republic of Korea"},{"name":"Research Institute for Drug Development Pusan National University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49698-4"},{"issue":"5","key":"e_1_2_10_3_1","first-page":"S122","article-title":"BPH: Epidemiology and Comorbidities","volume":"12","author":"McVary K. 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A.","year":"2004","journal-title":"Reviews in Urology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03429-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e95"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.07.062"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15570"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06448.x"},{"key":"e_1_2_10_17_1","first-page":"1601","article-title":"The Efficacy and Safety of Silodosin in Treating BPH: A Systematic Review and Meta\u2010Analysis","volume":"44","author":"Cui Y.","year":"2012","journal-title":"International Urology and Nephrology"},{"issue":"1","key":"e_1_2_10_18_1","first-page":"S10","article-title":"A Large Retrospective Analysis of Acute Urinary Retention and Prostate\u2010Related Surgery in BPH Patients Treated With 5\u2010Alpha Reductase Inhibitors: Dutasteride Versus Finasteride","volume":"13","author":"Issa M. M.","year":"2007","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-016-0170-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eursup.2006.05.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.084"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169248"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.09.091"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.579899"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.19.2319"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287220929486"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.70030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T02:32:22Z","timestamp":1758853942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.70030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/luts.70030"],"URL":"https:\/\/doi.org\/10.1111\/luts.70030","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"type":"print","value":"1757-5664"},{"type":"electronic","value":"1757-5672"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70030"}}