{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T03:10:07Z","timestamp":1758856207604,"version":"3.44.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Overactive bladder (OAB) is a prevalent and burdensome condition associated with significant impairments in health\u2010related quality of life and substantial healthcare costs. While third\u2010line therapies such as intravesical onabotulinum toxin A (BTA) and sacral neuromodulation are established treatment options for refractory cases, selective bladder denervation (SBD) via radiofrequency ablation (RFA) has emerged as a novel minimally invasive alternative. This study aimed to prospectively compare the efficacy and safety of SBD versus BTA in women with refractory OAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized controlled trial, 54 women with refractory OAB were allocated to receive either SBD or BTA. Patients were followed for 12\u2009weeks and assessed for changes in urgency episodes, urgency urinary incontinence (UUI), daily voiding frequency, overactive bladder symptom scores (OAB\u2010V8), quality of life (I\u2010QOL), post\u2010void residual (PVR) volume, and treatment\u2010emergent adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both interventions resulted in significant symptom improvement relative to baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, BTA demonstrated superior therapeutic efficacy, with a significantly higher proportion of patients achieving \u2265\u200950% reductions in urgency and UUI episodes across all follow\u2010up visits (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, BTA yielded greater improvements in symptom scores and quality of life indices. Adverse events were infrequent and mild in both groups. The BTA group exhibited a transient increase in PVR at early follow\u2010up, though no cases of acute urinary retention necessitating catheterization were observed. The SBD group showed modest symptom relief with stable objective parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this prospective randomized trial, intravesical BTA provided superior clinical efficacy compared to SBD across both subjective and objective outcome measures in women with refractory OAB. While SBD may represent a minimally invasive option for select patient populations, BTA remains the more effective third\u2010line intervention. Further large\u2010scale, sham\u2010controlled studies with longer follow\u2010up are warranted to clarify the role of SBD and optimize patient selection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.70032","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:15:07Z","timestamp":1758708907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective Bladder Denervation via Radiofrequency Ablation Versus Intravesical Onabotulinum Toxin A for Refractory Overactive Bladder: The Short\u2010Term Results of A Preliminary Randomized Controlled Trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Salih Zeki","family":"S\u00f6nmez","sequence":"first","affiliation":[{"name":"Department of Urology K\u0131rklareli Training and Research Hospital  K\u0131rklareli T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130smail","family":"Ulus","sequence":"additional","affiliation":[{"name":"Department of Urology University of Health Sciences, Istanbul Bagcilar Training and Research Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aykut","family":"\u00c7olakerol","sequence":"additional","affiliation":[{"name":"Department of Urology University of Health Sciences, Istanbul Bagcilar Training and Research Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Zafer","family":"Temiz","sequence":"additional","affiliation":[{"name":"Department of Urology University of Health Sciences, Istanbul Bagcilar Training and Research Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9924-6214","authenticated-orcid":false,"given":"Enes","family":"Pay","sequence":"additional","affiliation":[{"name":"Department of Urology University of Health Sciences, Istanbul Bagcilar Training and Research Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-4155","authenticated-orcid":false,"given":"Muhammet Murat","family":"Din\u00e7er","sequence":"additional","affiliation":[{"name":"Department of Urology University of Health Sciences, Istanbul Bagcilar Training and Research Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02243-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02228.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"issue":"3","key":"e_1_2_7_5_1","first-page":"433","article-title":"The Impact of Overactive Bladder on Mental Health, Work Productivity and Health\u2010Related Quality of Life in the UK and Sweden: A Cross\u2010Sectional, Population\u2010Based Study","volume":"111","author":"Coyne K. 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