{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:00:42Z","timestamp":1774591242152,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      In this study, we aimed to investigate the impact of vibegron, a \u03b2\n                      <jats:sub>3<\/jats:sub>\n                      \u2010adrenergic receptor agonist, on lower urinary tract dysfunction in a diabetic rat model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Female rats were categorized into three groups: non\u2010diabetic controls (N), streptozotocin\u2010induced diabetic rats receiving vehicle (D), and diabetic rats treated with vibegron (DV). In the DV group, vibegron was administered orally at 30\u2009mg\/kg\/day starting 7\u20138\u2009weeks after diabetes induction. At 8\u2009weeks post\u2010induction, voiding assays, urinary 8\u2010hydroxydeoxyguanosine (8\u2010OHdG) measurements, cystometry, and analysis of bladder mRNA expression levels of ischemia\u2010 and inflammatory\u2010related markers were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 24\u2010h voiding assays showed that Groups D and DV had markedly higher urine volume, average voided volume, voiding frequency, and water intake compared to Group N. Urinary 8\u2010OHdG levels were markedly elevated in Group D than those in Groups N and DV. Group D also exhibited higher opening pressure and non\u2010voiding contractions. Intercontraction intervals, voided volume, post\u2010void residual volume, bladder capacity, and compliance were significantly increased, while voiding efficiency was markedly decreased in Groups D and DV compared to that in Group N. Bladder mRNA expression of hypoxia\u2010inducible factor\u20101 alpha\n                      <jats:italic>(Hif1a)<\/jats:italic>\n                      , vascular endothelial growth factor A (\n                      <jats:italic>Vegfa<\/jats:italic>\n                      ), transforming growth factor\u2010beta 1 (\n                      <jats:italic>Tgfb1<\/jats:italic>\n                      ), and tumor necrosis factor alpha (\n                      <jats:italic>Tnfa<\/jats:italic>\n                      ) was upregulated in Group D compared with that in Groups N and DV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that vibegron may be a promising therapeutic option for addressing detrusor overactivity, ischemia, and inflammation of the bladder associated with diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.70051","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:56:09Z","timestamp":1770620169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Vibegron, a \u03b2\n                    <sub>3<\/sub>\n                    \u2010Adrenoceptor Agonist, on Lower Urinary Tract Dysfunction in Diabetic Rats"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-3820","authenticated-orcid":false,"given":"Daisuke","family":"Gotoh","sequence":"first","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Torimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Prefecture General Center  Nara 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