{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:13:52Z","timestamp":1780622032323,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["TCMF\u2010MP 114\u201002\u201001"],"award-info":[{"award-number":["TCMF\u2010MP 114\u201002\u201001"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To estimate response to intravesical onabotulinumtoxinA (BoNT\u2010A) injection and platelet\u2010rich plasma (PRP) therapy in females with bladder pain syndrome (BPS) without Hunner lesions, we developed and internally validated treatment\u2010specific predictive models integrating clinical characteristics, bladder functional parameters, and urinary biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Females with BPS who underwent intravesical BoNT\u2010A injection or PRP therapy were retrospectively analyzed. A total of 273 female patients were included in the final analysis. Multivariable logistic regression models were constructed to predict treatment response, defined as a Global Response Assessment score\u2009\u2265\u20092. Model discrimination was assessed using the area under the receiver operating characteristic (ROC) curve. For interpretability, nomogram visualizations and a conceptual framework are provided in the .<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The BoNT\u2010A model demonstrated acceptable discrimination (area under the ROC curve: 0.789), whereas the PRP model showed superior discriminatory performance (area under the ROC curve: 0.895). Distinct clinical features and biomarker patterns contributed to each treatment\u2010specific model, suggesting differential underlying mechanisms. Internal validation revealed higher observed response rates when the administered therapy matched the model\u2010predicted higher probability of response, supporting internal model concordance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment\u2010specific models combining clinical, urodynamic, and urinary biomarker data provide mechanistic insight into heterogeneous response profiles to BoNT\u2010A and PRP in females with BPS. While these models may inform future phenotype\u2010guided research and prospective validation, external validation is required before broader clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.70057","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:49:32Z","timestamp":1773478172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment\u2010Specific Clinical and Urinary Biomarker Signatures Associated With Response to Intravesical Botulinum Toxin A and Platelet\u2010Rich Plasma in Bladder Pain Syndrome"],"prefix":"10.1111","volume":"18","author":[{"given":"Wan\u2010Ru","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Nursing, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation, Tzu Chi University  Hualien Taiwan"},{"name":"Department of Nursing Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Cheng","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation, Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation, Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-024-01485-w"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-025-01044-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12040466"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1232017"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12532"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002756"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287221998134"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/us9.0000000000000057"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.05.019"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-023-00976-8"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-025-05888-8"},{"issue":"2","key":"e_1_2_12_13_1","first-page":"369","article-title":"Clustering of Urinary Biomarkers to Identify Interstitial Cystitis Subtypes and Different Clinical Characteristics and Treatment Outcomes","volume":"13","author":"Tian J. 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