{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:48:18Z","timestamp":1787168898273,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess rates of medication use for lower urinary tract symptoms (LUTS) over time following laser enucleation of the prostate (LEP) and to identify preoperative predictors of persistent use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 864 LEP patients from an institutional tertiary\u2010care database (11\/2017\u201305\/2023) with available 24\u2010month follow\u2010up on medication use. Patient\u2010reported use of five drug classes (alpha\u2010blockers, 5\u2010alpha\u2010reductase (AR)\u2010inhibitors, anticholinergics, beta\u20103\u2010agonists, and phosphodiesterase (PDE)\u20105\u2010inhibitors) was recorded preoperatively and at one, three, 12, and 24\u2009months after the procedure. Univariable and multivariable logistic regression models were fitted to identify predictors of persistent LUTS medication use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Preoperatively, 84.9% of patients used LUTS medication, decreasing to 12.6% within 24\u2009months of follow\u2010up. Alphablocker (80.9%) and 5\u2010AR\u2010inhibitor (13.8%) use declined to 1.8% and 0%, respectively. Anticholinergic (4.6%) and beta\u20103\u2010agonist (0.3%) use showed a transient postoperative increase with peaks of 10.9% and 1.0% at 3 months, followed by a decline to 2.7% and 0.4% at 24\u2009months, respectively. PDE\u20105\u2010inhibitor use (1.8%) increased steadily to 5.4% at 24\u2009months. Patient with persistent use exhibited worse baseline QoL and ICIQ\u2010SF scores and higher rates of adiposity, diabetes mellitus, and ASA score III\/IV. In multivariable analysis, only preoperative PDE\u20105\u2010inhibitor use (adjusted OR 3.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and ASA score III\/IV (adjusted OR 2.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) remained independently associated with persistent LUTS medication use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LUTS medication use decreased substantially after LEP, with only a small subset requiring continued medication at 24\u2009months. Preoperative PDE\u20105\u2010inhibitor use and higher comorbidity burden emerged as independent predictors of persistent LUTS medication use. These findings can refine preoperative counseling regarding postoperative LUTS medication dependence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.70062","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:01:02Z","timestamp":1776927662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rates and Predictors of Persistent\n                    <scp>LUTS<\/scp>\n                    Medication Use After Laser Enucleation of the Prostate"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5715-9965","authenticated-orcid":false,"given":"Maximilian","family":"Filzmayer","sequence":"first","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam I.","family":"Traumann","sequence":"additional","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Humke","sequence":"additional","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp C.","family":"Mandel","sequence":"additional","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Martini Clinic Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Kluth","sequence":"additional","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Department of Urology Asklepios Paulinen Clinic  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Urological Center at Boxberg  Neunkirchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix K.\u2010H.","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Kosiba","sequence":"additional","affiliation":[{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"European Association of Urology: EAU Guidelines \u201cEdition Presented at the EAU Annual Congress in Madrid 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