{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:59:51Z","timestamp":1785416391181,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014984","name":"Wuhu Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022cg29"],"award-info":[{"award-number":["2022cg29"]}],"id":[{"id":"10.13039\/501100014984","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The benefit of transurethral outlet surgery in men with benign prostatic enlargement\/benign prostatic obstruction (BPE\/BPO) and detrusor underactivity (DU) remains uncertain, particularly when bladder outlet obstruction (BOO) is not demonstrated by pressure\u2010flow testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate early outcomes after transurethral thulium laser enucleation of the prostate (ThuLEP) in men with DU and BPE\/BPO\u2010related voiding dysfunction, and to examine whether BOOI\u2010defined obstruction status stratifies early postoperative improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 189 ThuLEP records from a single centre and constructed a 100\u2010patient complete\u2010case cohort with interpretable preoperative pressure\u2010flow studies and 3\u2010month follow\u2010up. DU was defined as bladder contractility index (BCI) &lt;\u2009100. BOO status was classified using bladder outlet obstruction index (BOOI) as definite BOO, equivocal BOO or no BOO. Functional, symptom, catheter\u2010removal, anatomical and safety outcomes were compared descriptively across BOO strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010one patients (91.0%) had DU: 56 had definite BOO, 25 had equivocal BOO and 10 had no BOO. In the DU cohort, mean\n                      <jats:italic>Q<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      increased from 3.88\u2009\u00b1\u20091.76\u2009mL\/s at baseline to 9.98\u2009\u00b1\u20093.68\u2009mL\/s at 1\u2009month and 11.03\u2009\u00b1\u20094.02\u2009mL\/s at 3\u2009months (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Mean PVR decreased from 267.8\u2009\u00b1\u2009167.4 to 142.6\u2009\u00b1\u2009115.3\u2009mL and 124.7\u2009\u00b1\u2009103.4\u2009mL, respectively (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). IPSS and QoL also improved. Because enucleated specimen weight was unavailable, postoperative prostate volume was analyzed as an anatomical surrogate; mean 3\u2010month postoperative prostate volume was 18.8\u2009\u00b1\u20094.3\u2009mL, corresponding to an absolute volume reduction of 38.0\u2009\u00b1\u200914.2\u2009mL and a percentage reduction of 65.4%\u2009\u00b1\u20096.3% in the DU cohort. Catheter\u2010removal success was 83.9% in definite BOO, 68.0% in equivocal BOO and 40.0% in no BOO patients (descriptive\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative BOOI\u2010based stratification may help counsel men with DU regarding expected early functional improvement after ThuLEP. BOOI\u2010defined no\u2010BOO patients in this cohort were clinically selected after counseling, and the findings should be interpreted as exploratory because of the retrospective design, complete\u2010case selection, short follow\u2010up, and the small no\u2010BOO subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.70073","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:07:26Z","timestamp":1781258846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>BOOI\u2010Defined<\/scp>\n                    Obstruction Stratifies Early Outcomes After\n                    <scp>ThuLEP<\/scp>\n                    in Men With Detrusor Underactivity: A Retrospective Complete\u2010Case Cohort Study"],"prefix":"10.1111","volume":"18","author":[{"given":"Wei","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Urology The Second People's Hospital, WuHu\/WuHu Hospital, East China Normal University (The Second People's Hospital, WuHu)  Wuhu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology The Second People's Hospital, WuHu\/WuHu Hospital, East China Normal University (The Second People's Hospital, WuHu)  Wuhu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology The Second People's Hospital, WuHu\/WuHu Hospital, East China Normal University (The Second People's Hospital, WuHu)  Wuhu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology The Second People's Hospital, WuHu\/WuHu Hospital, East China Normal University (The Second People's Hospital, WuHu)  Wuhu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-5723","authenticated-orcid":false,"given":"Jiawei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology The Second People's Hospital, WuHu\/WuHu Hospital, East China Normal University (The Second People's Hospital, WuHu)  Wuhu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology The Second People's Hospital, WuHu\/WuHu Hospital, East China Normal University (The Second People's Hospital, WuHu)  Wuhu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-6649","authenticated-orcid":false,"given":"Lingsong","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Urology The Second People's Hospital, WuHu\/WuHu Hospital, East China Normal University (The Second People's Hospital, WuHu)  Wuhu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.10.015"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.156"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23701"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.07.037"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010024\u201002514\u20103"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.07.079"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2018.12.005"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.09.030"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12282"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24526"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24470"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25253"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25336"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201004237\u20100"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_115_16"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2003.04719.x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000434688"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16346"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464\u2010410x.1999.00121.x"},{"key":"e_1_2_13_22_1","volume-title":"EAU Guidelines on the Management of Non\u2010Neurogenic Male LUTS","author":"European Association of Urology","year":"2026"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.04.004"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000246"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003698"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.10.022"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.70073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/luts.70073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:59:51Z","timestamp":1785412791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/luts.70073"],"URL":"https:\/\/doi.org\/10.1111\/luts.70073","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]},"assertion":[{"value":"2026-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70073"}}