{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:27:10Z","timestamp":1790285230250,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate sexual function and clinical outcomes following Rez\u016bm water vapor thermal therapy (WVTT) for benign prostatic hyperplasia (BPH), with a dedicated focus on patients with large prostate volumes (&gt;\u200980\u2009mL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search on PubMed, Scopus, and EBSCOhost was conducted through June 23, 2026. Studies reporting validated patient\u2010reported outcome measures for erectile (IIEF) and ejaculatory (MSHQ\u2010EjD) functions were included. Methodological quality was appraised using the Newcastle\u2013Ottawa Scale (NOS) for 27 cohorts and the Cochrane RoB 2 tool for three randomized controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty studies (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094635 patients) met inclusion criteria. Across gland sizes (30\u2013150\u2009mL), Rez\u016bm demonstrated a consistent trend toward preservation of erectile and ejaculatory function. Although several studies reported statistically significant improvements in IIEF scores, these generally did not reach established thresholds for clinical significance. Ejaculatory function was preserved in the majority of patients, contrasting with high rates of ejaculatory dysfunction reported for resective comparators. Ten studies provided data for prostates &gt;\u200980\u2009mL; in this subgroup, Rez\u016bm provided significant relief of lower urinary tract symptoms (LUTS) with sexual function outcomes that appeared comparable to those in standard\u2010sized glands. Adverse events were predominantly Clavien\u2010Dindo Grade I\u2013II, with Grade \u2265 III complications occurring in &lt;\u20091% of patients. Overall, methodological quality was limited, with a high prevalence of low\u2010to\u2010moderate quality evidence, and all RCTs judged at high risk of bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current evidence suggests that Rez\u016bm preserves erectile and ejaculatory function while providing meaningful relief of urinary symptoms, including in large\u2010volume prostates. However, confidence in these findings remains limited by the predominance of low\u2010quality evidence and a high risk of bias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.70081","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:20:17Z","timestamp":1784676017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sexual Function and Clinical Outcomes Following Rez\u016bm Therapy for Benign Prostatic Hyperplasia: An Updated Systematic Review Including Large Prostate Volumes"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-4862","authenticated-orcid":false,"given":"Ivan Maulana","family":"Fakh","sequence":"first","affiliation":[{"name":"Department of Urology Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4458-4055","authenticated-orcid":false,"given":"Harrina Erlianti","family":"Rahardjo","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934\u2010014\u20100441\u20102"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934\u2010018\u20100813\u20100"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2021.21128"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S143679"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.20200392"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15753"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.02.001"},{"key":"e_1_2_11_9_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. 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