{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:46:46Z","timestamp":1792010806013,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the 3\u2010year functional outcomes of Aquablation\/AquaBeam waterjet therapy for bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH), with particular attention to urinary symptoms, quality of life, continence, ejaculatory function, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of a prospectively maintained multicenter database including 218 consecutive men who underwent Aquablation\/AquaBeam for symptomatic BPH between January 2019 and January 2022 at three referral centers. Functional outcomes assessed preoperatively and during follow\u2010up included International Prostate Symptom Score (IPSS), IPSS quality\u2010of\u2010life item (IPSS\u2010QoL), maximum urinary flow rate (Qmax), post\u2010void residual urine (PVR), continence, and ejaculatory function. Median follow\u2010up was 36\u2009months. Ejaculatory preservation was evaluated only in patients with preserved antegrade ejaculation at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age was 61\u2009years (IQR 57\u201366), median prostate\u2010specific antigen (PSA) was 2.52\u2009ng\/mL (IQR 0.40\u201321.60), and median prostate volume was 55\u2009mL (IQR 40\u201373). Median operative time was 56\u2009min, while median catheterization time and length of hospital stay were both 48\u2009h. Functional improvements were evident from the 3\u2010month follow\u2010up and remained stable through 36\u2009months. At 36\u2009months, median IPSS improved to 5 and median Qmax to 18\u2009mL\/s. Median PSA changed modestly from 2.52\u2009ng\/mL at baseline to 2.75\u2009ng\/mL at 36\u2009months. No cases of de novo urinary incontinence were observed throughout follow\u2010up. Among patients with preserved antegrade ejaculation at baseline, 87% maintained antegrade ejaculation at 36\u2009months. Most postoperative complications were minor (Clavien\u2010Dindo grade I\u2010II, 20.2%). One grade III rectal injury occurred (0.5%). Median hemoglobin decreased from 15.2\u2009g\/dL preoperatively to 14.0\u2009g\/dL before hospital discharge, and two patients required blood transfusion. During the 36\u2010month follow\u2010up, no surgical retreatment was required, whereas 11 patients (5.0%) received temporary medical retreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this multicenter real\u2010world cohort, Aquablation\/AquaBeam was safe and effective over 3\u2009years, providing durable improvement in lower urinary tract symptoms and quality of life while preserving continence and antegrade ejaculation in most patients. These findings support Aquablation\/AquaBeam as a valuable minimally invasive surgical option for selected men with BPH, particularly those who prioritize preservation of ejaculatory function. Longer\u2010term and comparative studies are warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>48281<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.70088","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:37:52Z","timestamp":1787031472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aquablation\/\n                    <scp>AquaBeam<\/scp>\n                    Waterjet Therapy for Benign Prostatic Hyperplasia: Three\u2010Year Functional and Ejaculatory Outcomes in a Multicenter Real\u2010World Italian Cohort"],"prefix":"10.1111","volume":"18","author":[{"given":"Angelo","family":"Porreca","sequence":"first","affiliation":[{"name":"Department of Urology Humanitas Gavazzeni  Bergamo Italy"},{"name":"Humanitas University  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Department of Urology Humanitas Gavazzeni  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"De Marchi","sequence":"additional","affiliation":[{"name":"Department of Urology Humanitas Gavazzeni  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Giampaoli","sequence":"additional","affiliation":[{"name":"Department of Urology Humanitas Gavazzeni  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Urology Humanitas Gavazzeni  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Busetto","sequence":"additional","affiliation":[{"name":"Department of Urology University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2730-0402","authenticated-orcid":false,"given":"Antonio","family":"Amodeo","sequence":"additional","affiliation":[{"name":"Veneto Institute of Oncology \u2010 IRCCS (IOV), Department of Oncological Urology  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Corsi","sequence":"additional","affiliation":[{"name":"Veneto Institute of Oncology \u2010 IRCCS (IOV), Department of Oncological Urology  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-5553","authenticated-orcid":false,"given":"Francesco","family":"Claps","sequence":"additional","affiliation":[{"name":"Veneto Institute of Oncology \u2010 IRCCS (IOV), Department of Oncological Urology  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-7415","authenticated-orcid":false,"given":"Luca","family":"Di Gianfrancesco","sequence":"additional","affiliation":[{"name":"Department of Urology Humanitas Gavazzeni  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Management of Non\u2010neurogenic Male LUTS \u201cEAU Guidelines \u201dEdn. presented at the EAU Annual Congress Paris April 2024. ISBN 978\u201394\u201392671\u201023\u20103."},{"issue":"6","key":"e_1_2_13_3_1","first-page":"8590","article-title":"How I Do It: Aquablation of the Prostate Using the AQUABEAM System","volume":"23","author":"MacRae C.","year":"2016","journal-title":"Canadian Journal of Urology"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja202357"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2019.05.014"},{"issue":"2","key":"e_1_2_13_6_1","first-page":"10610","article-title":"Focal Bladder Neck Cautery Associated With Low Rate of Post\u2010Aquablation Bleeding","volume":"28","author":"Elterman D. 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