{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:59:38Z","timestamp":1790315978882,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To investigate the nationwide trends in pharmacological treatment for overactive bladder among Japanese adults, specifically focusing on the \u03b23\u2010agonists to anticholinergics prescribed tablet ratio (BAPR) and how this ratio differs by sex and age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>National Database Open Data from fiscal year 2015 to 2023 were utilized and the prescription volumes of \u03b23\u2010agonists (mirabegron and vibegron) and anticholinergics (propiverine, solifenacin, imidafenacin, and fesoterodine) were aggregated. The data were categorized by sex and 10\u2010year age groups to analyze prescribed tablet trends per 1000 population for each demographic. We calculated the BAPR by dividing the number of prescribed tablets for \u03b23\u2010agonists by those for anticholinergics and investigated the annual trends for younger and older men and women using an ordinary least squares linear regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, the total number of prescribed tablets for \u03b23\u2010agonists, anticholinergics, and overall total showed changes of +285.3%, \u221224.7%, and +59.3%, respectively. Total and \u03b23\u2010agonist prescriptions rose annually across all groups, whereas anticholinergic use declined beginning in fiscal year 2018. Additionally, nearly all drugs showed an increase in prescribed tablets per 1000 population as age progressed. Although the BAPR increased significantly in all groups, there were significant differences in the rates of change between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with older men exhibiting the highest rate of increase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A nationwide shift in overactive bladder treatment, where the growth in \u03b23\u2010agonist prescriptions outweighed the decline in anticholinergics, was observed across all demographic groups in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.70092","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T22:51:22Z","timestamp":1787179882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010 and Age\u2010Specific Trends in Prescriptions of Beta\u20103 Agonists and Anticholinergics in Japan: A Nationwide Prescription Database Study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-8934","authenticated-orcid":false,"given":"Minato","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Onuki","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisaki","family":"Koshi","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorami","family":"Tsukahara","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Negami","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8851-320X","authenticated-orcid":false,"given":"Yuichiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4904-0685","authenticated-orcid":false,"given":"Akihiro","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumasa","family":"Amemiya","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunehiro","family":"Nenohi","sequence":"additional","affiliation":[{"name":"Department of Urology Teikyo University Hospital, Mizonokuchi  Kawasaki 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