{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:59:40Z","timestamp":1790315980121,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To synthesize published placebo\u2010controlled trials of vibegron monotherapy for overactive bladder (OAB) and quantify posterior probabilities of benefit and decision\u2010threshold exceedance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We extracted published placebo\u2010adjusted least\u2010squares mean differences at Week 12 from three randomized, double\u2010blind, placebo\u2010controlled Phase III trials evaluating vibegron monotherapy (Japan Phase III trial, Korea bridging study [50\u2009mg], and EMPOWUR trial [75\u2009mg]) for four voiding\u2010diary endpoints: micturitions\/day, urgency episodes\/day, urgency urinary incontinence (UUI) episodes\/day, and voided volume (mL). For each endpoint, a Bayesian normal\u2013normal random\u2010effects model estimated the pooled mean effect and between\u2010trial heterogeneity and calculated posterior probabilities of benefit and of exceeding thresholds predefined in this analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pooled mean effects (95% credible intervals) favored vibegron across all four voiding\u2010diary endpoints: micturitions\/day (\u22120.76, \u22121.33 to \u22120.28), urgency episodes\/day (\u22120.69, \u22121.35 to \u22120.22), UUI episodes\/day (\u22120.44, \u22120.93 to \u22120.03), and voided volume (+24.09\u2009mL, 15.78\u201332.51). The posterior probabilities of benefit were 99.5%, 99.3%, 98.0%, and &gt;\u200999.9%, respectively. The probabilities of exceeding thresholds were as follows: for micturitions\/day, \u2264\u2009\u22120.5: 90.3% and \u2264\u2009\u22121.0: 14.2%; for urgency episodes\/day, \u2264\u2009\u22120.5: 82.8% and \u2264\u2009\u22121.0: 12.7%; for UUI episodes\/day, \u2264\u2009\u22120.3: 81.8% and \u2264\u2009\u22120.5: 35.4%; and for voided volume, \u2265\u2009+10\u2009mL: 99.5%, \u2265\u2009+20\u2009mL: 88.4%, and \u2265\u2009+30\u2009mL: 5.8%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bayesian cross\u2010trial synthesis demonstrates a high probability that vibegron improves key OAB voiding\u2010diary outcomes at Week 12. By explicitly quantifying the probability of exceeding clinically interpretable decision thresholds, this approach provides a transparent assessment of both the direction and magnitude of treatment effects, facilitating clinically interpretable decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/luts.70095","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:51:07Z","timestamp":1787968267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Vibegron in Overactive Bladder: A Bayesian Cross\u2010Trial Synthesis of Benefit Probabilities and Decision Thresholds"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6403-8719","authenticated-orcid":false,"given":"Takanobu","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"},{"name":"Department of Urology Tokyo Metropolitan Tama\u2010Nambu Chiiki Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-8083","authenticated-orcid":false,"given":"Soichiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2300-8446","authenticated-orcid":false,"given":"Shugo","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of Urology National Cancer Center Hospital East  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-1580","authenticated-orcid":false,"given":"Hiroshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo 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