{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:24:34Z","timestamp":1790043874157,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of prophylactic iron during pregnancy on maternal and child health in developing settings with endemic malaria and high prevalence of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> remain unclear. This paper describes the rationale, implementation and success of a pragmatic randomised controlled trial comparing routine iron supplementation vs. screening and treatment for anaemia during pregnancy. The setting was two health centres in <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>aputo, <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ozambique. Pregnant women (\u226512\u2010week gestation; \u226518 years old; and not with a high\u2010risk pregnancy, <jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u20094326) were recruited. The main outcomes are preterm delivery and low birthweight. The women were randomly assigned to one of two iron administration policies: a routine iron group (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u20092184) received 60\u2009<jats:styled-content style=\"fixed-case\">mg<\/jats:styled-content> of ferrous sulphate plus 400\u2009<jats:styled-content style=\"fixed-case\">\u03bcg<\/jats:styled-content> of folic acid daily while a selective iron group (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u20092142) had screening and treatment for anaemia and a daily intake of 1\u2009<jats:styled-content style=\"fixed-case\">mg<\/jats:styled-content> of folic acid. The recruitment, follow\u2010up, and collection of follow\u2010up data were successful; both groups were similar to each other in all the trial stages. Collection of delivery data was challenging and data on about 40% of births is missing. These are currently being traced through different hospitals and health centres. The compliance of the study personnel and the women with regard to regular measurement of haemoglobin and intake of the iron and folic acid tablets was high and similar in both trial arms. Taking into account the various constraints encountered, the stages of the present trial prior to delivery were carried out well.<\/jats:p>","DOI":"10.1111\/mcn.12006","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T08:01:19Z","timestamp":1349078479000},"page":"146-163","source":"Crossref","is-referenced-by-count":4,"title":["A pragmatic randomised controlled trial on routine iron prophylaxis during pregnancy in <scp>M<\/scp>aputo, <scp>M<\/scp>ozambique (<scp>PROFEG<\/scp>): rationale, design, and success"],"prefix":"10.1111","volume":"11","author":[{"given":"Bright I.","family":"Nwaru","sequence":"first","affiliation":[{"name":"School of Health Sciences University of Tampere  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Parkkali","sequence":"additional","affiliation":[{"name":"Health Services and Policy Research National Institute for Health and Welfare  Helsinki 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