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The W<\/jats:styled-content>orld H<\/jats:styled-content>ealth O<\/jats:styled-content>rganization endorses home fortification with MNP<\/jats:styled-content>s containing at least iron, vitamin A<\/jats:styled-content> and zinc to control childhood anaemia, and calls for concomitant malaria control strategies in malaria endemic regions. Among other micronutrients, current MNP<\/jats:styled-content> formulations generally include 88\u2009\u03bc<\/jats:italic>g folic acid (corresponding to 100% of the R<\/jats:styled-content>ecommended N<\/jats:styled-content>utrient I<\/jats:styled-content>ntake). The risks and benefits of providing supplemental folic acid at these levels are unclear. The limited data available indicate that folate deficiency may not be a major public health problem among children living in sub\u2010S<\/jats:styled-content>aharan A<\/jats:styled-content>frica and supplemental folic acid may therefore not have any benefits. Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour P<\/jats:styled-content>lasmodium falciparum<\/jats:italic> growth, inhibit parasite clearance of sulphadoxine\u2010pyrimethamine (SP<\/jats:styled-content>)\u2010treated malaria and increase subsequent recrudescence. Even though programmatic options to limit prophylactic SP<\/jats:styled-content> use or to promote the use of insecticide treated bed nets may render the use of folic acid safer, programmatic barriers to these approaches are likely to persist. Research is needed to characterise the prevalence of folate deficiency among young children worldwide and to design safe MNP<\/jats:styled-content> and other types of fortification approaches in sub\u2010S<\/jats:styled-content>ahara A<\/jats:styled-content>frica. In parallel, updated global guidance is needed for MNP<\/jats:styled-content> programmes in these regions.<\/jats:p>","DOI":"10.1111\/mcn.12102","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T08:58:17Z","timestamp":1382086697000},"page":"1-15","source":"Crossref","is-referenced-by-count":14,"title":["The role of folate in malaria \u2013 implications for home fortification programmes among children aged 6\u201359 months"],"prefix":"10.1111","volume":"11","author":[{"given":"Roland","family":"Kupka","sequence":"first","affiliation":[{"name":"UNICEF Regional Office for West and Central Africa Dakar Senegal"},{"name":"Department of Nutrition Harvard School of Public Health Boston Massachusettes USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1990.11747441"},{"key":"e_1_2_11_3_1","first-page":"1432","article-title":"Plasma homocysteine levels in cardiovascular disease, malaria and protein\u2010energy malnutrition in Sudan","volume":"15","author":"Abdel G.A.","year":"2009","journal-title":"Eastern Mediterranean Health Journal"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.2.412"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.929"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.9.3000S"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102875\u20104\u201036"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S117"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61690-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/ajcn\/35.1.146","article-title":"Hypothesis: the importance of folacin in influencing susceptibility to malarial infection in infants","volume":"35","author":"Brabin B.J.","year":"1982","journal-title":"The American Journal of Clinical Nutrition"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90182-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/ajcn\/43.5.803","article-title":"Folacin, cobalamin, and hematological status during pregnancy in rural Kenya: the influence of parity, gestation, and Plasmodium falciparum malaria","volume":"43","author":"Brabin B.J.","year":"1986","journal-title":"The American Journal of Clinical Nutrition"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/00034983.1985.11811964","article-title":"Malaria chemoprophylaxis with chloroquine in young Nigerian children. 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