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Women (<jats:italic>n<\/jats:italic>\u2009=\u20091320) received either 60\u2009mg Fe\u2009+\u2009400\u2010\u00b5g folic acid (IFA); 18 micronutrients including 20\u2010mg Fe (MMN) or small\u2010quantity lipid\u2010based nutrient supplements (SQ\u2010LNS, 118\u2009kcal\/d) with the same micronutrient levels as in MMN, plus four additional minerals (LNS) daily during pregnancy. Intention\u2010to\u2010treat analysis included 349, 354 and 354 women in the IFA, MMN and LNS groups, respectively, with overall baseline mean Hb and anemia (Hb &lt;100) prevalence of 112 and 13.3%, respectively. At 36 gestational weeks, overall Hb was 117, and anemia prevalence was 5.3%. Compared with the IFA group, the LNS and MMN groups had lower mean Hb (120\u2009\u00b1\u200911 vs. 115\u2009\u00b1\u200912 and 117\u2009\u00b1\u200912, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), higher mean ZPP (42\u2009\u00b1\u200930 vs. 50\u2009\u00b1\u200929 and 49\u2009\u00b1\u200930; <jats:italic>P<\/jats:italic>\u2009=\u20090.010) and TfR (4.0\u2009\u00b1\u20091.3 vs. 4.9\u2009\u00b1\u20091.8 and 4.6\u2009\u00b1\u20091.7; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and greater prevalence of anemia (2.2% vs. 7.9% and 5.8%; <jats:italic>P<\/jats:italic>\u2009=\u20090.019), elevated ZPP (&gt;60) [9.4% vs. 18.6% and 19.2%; <jats:italic>P<\/jats:italic>\u2009=\u20090.003] and elevated TfR (&gt;6.0) [9.0% vs. 19.2% and 15.1%; <jats:italic>P<\/jats:italic>\u2009=\u20090.004]. CRP and AGP concentrations did not differ among groups. We conclude that among pregnant women in a semi\u2010urban setting in Ghana, supplementation with SQ\u2010LNS or MMN containing 20\u2009mg iron resulted in lower Hb and iron status but had no impact on inflammation, when compared with iron (60\u2009mg) plus folic acid (400\u2009\u00b5g). The amount of iron in such supplements that is most effective for improving both maternal Hb\/iron status and birth outcomes requires further evaluation. This trial was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> as: NCT00970866.<\/jats:p>","DOI":"10.1111\/mcn.12262","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T11:43:08Z","timestamp":1456746188000},"source":"Crossref","is-referenced-by-count":34,"title":["Impact of small\u2010quantity lipid\u2010based nutrient supplement on hemoglobin, iron status and biomarkers of inflammation in pregnant Ghanaian women"],"prefix":"10.1111","volume":"13","author":[{"given":"Seth","family":"Adu\u2010Afarwuah","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Science University of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lartey","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science University of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Okronipa","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science University of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Ashorn","sequence":"additional","affiliation":[{"name":"Center for Child Health Research and Department of Pediatrics University of Tampere School of Medicine and Tampere University Hospital  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamane","family":"Zeilani","sequence":"additional","affiliation":[{"name":"Nutriset S.A.S.  Malaunay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacey M.","family":"Baldiviez","sequence":"additional","affiliation":[{"name":"Program in International and Community Nutrition, Department of Nutrition University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brietta M.","family":"Oaks","sequence":"additional","affiliation":[{"name":"Program in International and Community Nutrition, Department of Nutrition University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Vosti","sequence":"additional","affiliation":[{"name":"Program in International and Community Nutrition, Department of Nutrition University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn G.","family":"Dewey","sequence":"additional","affiliation":[{"name":"Program in International and Community Nutrition, Department of Nutrition University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.091546"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1280s"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265090304S407"},{"key":"e_1_2_12_5_1","article-title":"Considerations in developing lipid\u2010based nutrient supplements for prevention of undernutrition: experience from the International Lipid\u2010Based Nutrient Supplements (iLiNS) Project","author":"Arimond M.","year":"2013","journal-title":"Maternal & Child Nutrition"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.1.173"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2004.11.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20051400"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01035.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.11.3492"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","unstructured":"CoatesJ. 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