{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:10:06Z","timestamp":1762542606868,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T00:00:00Z","timestamp":1481068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["552747\/2011\u20104","200487\/2015\u20109"],"award-info":[{"award-number":["552747\/2011\u20104","200487\/2015\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Home fortification with multiple micronutrient powder (MNP) is effective in the prevention of anemia in young children. However, the impact on their vitamin A status remains controversial. This study aimed to evaluate the effect of MNP on vitamin A status in young Brazilian children. A multicenter pragmatic, controlled trial was carried out in primary health centers in four Brazilian cities. In the beginning of the study, the control group (CG) consisted of children 11\u201314\u00a0months old (<jats:italic>n<\/jats:italic>\u00a0=\u00a0395) attending in routine pediatric health care. In parallel, the intervention group (IG) was composed of children 6\u20138\u00a0months old (<jats:italic>n<\/jats:italic>\u00a0=\u00a0399), in the same health centers, who followed the intervention with MNP for 2\u20133\u00a0months. The analysis of the effect of MNP on vitamin A status was performed by comparing the IG with the CG after a 4\u2010 to 6\u2010month follow\u2010up when IG children had reached the age of the controls. The prevalence of vitamin A deficiency (VAD; serum retinol &lt;0.70\u00a0\u03bcmol\/L) in the CG was 16.2%, while in the IG was 7.5%\u2014a 55% reduction in the VAD [prevalence ratio (95% confidence interval)\u00a0=\u00a00.45 (0.28; 0.72)]. This reduction was also significant when stratifying the study centers by coverage of the Brazilian Vitamin A Supplementation Program. The adjusted mean of vitamin A serum concentrations improved in the IG compared with CG children, with a shift to the right in the vitamin A distribution. Home fortification with MNP was effective in reducing VAD among young Brazilian children.<\/jats:p>","DOI":"10.1111\/mcn.12403","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T13:01:21Z","timestamp":1481115681000},"source":"Crossref","is-referenced-by-count":5,"title":["The impact of home fortification with multiple micronutrient powder on vitamin A status in young children: A multicenter pragmatic controlled trial in Brazil"],"prefix":"10.1111","volume":"13","author":[{"given":"Lara Livia Santos","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Public Health University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e2ngela Aparecida","family":"Augusto","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Cardoso","family":"Tietzmann","sequence":"additional","affiliation":[{"name":"Department of Nutrition Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldina Augusta Souza","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Department of Nutrition Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Claret Costa Monteiro","family":"Hadler","sequence":"additional","affiliation":[{"name":"School of Nutrition Federal University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascoal Torres","family":"Muniz","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Federal University of Acre  Rio Branco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Israel Cabral","family":"de Lira","sequence":"additional","affiliation":[{"name":"Department of Nutrition Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marly Augusto","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the ENFAC Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,7]]},"reference":[{"volume-title":"Cadernos de Aten\u00e7\u00e3o B\u00e1sica: Car\u00eancias de Micronutrientes","year":"2007","author":"Brasil (Minist\u00e9rio da Sa\u00fade) & United Nations Children's Fund (UNICEF)","key":"e_1_2_10_2_1"},{"volume-title":"Pesquisa Nacional de Demografia e Sa\u00fade da crian\u00e7a e da mulher\u2014PNDS 2006","year":"2009","author":"Brasil (Minist\u00e9rio da Sa\u00fade)","key":"e_1_2_10_3_1"},{"volume-title":"Manual de Condutas Gerais do Programa Nacional de Suplementa\u00e7\u00e3o de Vitamina A","year":"2013","author":"Brasil (Minist\u00e9rio da Sa\u00fade)","key":"e_1_2_10_4_1"},{"key":"e_1_2_10_5_1","unstructured":"Brasil (Minist\u00e9rio da Sa\u00fade).Vitamina A\u2014m\u00f3dulo gerador de relat\u00f3rios. 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