{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:33Z","timestamp":1787015733288,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["106446"],"award-info":[{"award-number":["106446"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    is important in fetal development, but little is known of the vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    status of pregnant women and newborns in North America and potential modifying factors. This prospective study determined maternal and cord plasma concentrations of pyridoxal 5\u2032 phosphate (PLP; an indicator of vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    status) in a convenience sample of 368 Canadian pregnant women and their newborns. The association of maternal intake of vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    and fetal genetic variants with cord plasma PLP and homocysteine concentrations was also examined. Dietary and supplemental intakes of vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    were assessed in early and mid to late pregnancy. PLP concentrations were measured in maternal plasma in early pregnancy and at delivery, and in cord plasma. Six fetal variants of the\n                    <jats:italic>MTHFR<\/jats:italic>\n                    and\n                    <jats:italic>C\u03b2S<\/jats:italic>\n                    genes were assessed for their association with cord plasma PLP and homocysteine concentrations. Geometric mean (95% CI) PLP concentrations were 107 (98, 116) nmol\/L in early pregnancy and 58 (53, 62) nmol\/L at delivery, respectively, and 296 (275, 319) nmol\/L in cord blood (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001). During early pregnancy and at delivery, 3.6% and 5.5% of women had plasma PLP concentrations &lt;20\u00a0nmol\/L, respectively. Ninety eight percent of the women with supplemental B\n                    <jats:sub>6<\/jats:sub>\n                    intake of at least the recommended dietary allowance had PLP concentrations &gt;20\u00a0nmol\/L. Fetal genetic variants were not associated with cord PLP and homocysteine concentrations. Vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    deficiency is uncommon in a cohort of Canadian pregnant women due largely to prevalent vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    supplement use.\n                  <\/jats:p>","DOI":"10.1111\/mcn.12467","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T12:44:12Z","timestamp":1495716252000},"source":"Crossref","is-referenced-by-count":9,"title":["Suboptimal maternal and cord plasma pyridoxal 5\u2032 phosphate concentrations are uncommon in a cohort of Canadian pregnant women and newborn infants"],"prefix":"10.1111","volume":"14","author":[{"given":"Lesley","family":"Plumptre","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto  Toronto Ontario Canada"},{"name":"Keenan Research Center for Biomedical Science of St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon P.","family":"Masih","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto  Toronto Ontario Canada"},{"name":"Keenan Research Center for Biomedical Science of St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung\u2010Jin","family":"Sohn","sequence":"additional","affiliation":[{"name":"Keenan Research Center for Biomedical Science of St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto  Toronto Ontario Canada"},{"name":"Keenan Research Center for Biomedical Science of St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly E.","family":"Visentin","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto  Toronto Ontario Canada"},{"name":"Keenan Research Center for Biomedical Science of St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ly","sequence":"additional","affiliation":[{"name":"Keenan Research Center for Biomedical Science of St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology St. Michael's Hospital &amp; University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Croxford","sequence":"additional","affiliation":[{"name":"Freelance Statistics Consultant  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah L.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto  Toronto Ontario Canada"},{"name":"Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-7281","authenticated-orcid":false,"given":"Young\u2010In","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto  Toronto Ontario Canada"},{"name":"Keenan Research Center for Biomedical Science of St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Division of Gastroenterology, Department of Medicine St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0009-9120(00)00161-2","article-title":"A method for homogeneous color\u2010compensated genotyping of factor V (G1691A) and methylenetetrahydrofolate reductase (C677T) mutations using real\u2010time multiplex fluorescence PCR","volume":"33","author":"Ahsen N.","year":"2000","journal-title":"Clinical Biochemistry"},{"key":"e_1_2_7_3_1","first-page":"199","article-title":"A randomized comparison of vitamin B6 and dimenhydrinate in the treatment of nausea and vomiting in early pregnancy","volume":"19","author":"Babaei A. 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