{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:24:41Z","timestamp":1784370281874,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["AID\u2010OAA\u2010A\u201012\u201000024"],"award-info":[{"award-number":["AID\u2010OAA\u2010A\u201012\u201000024"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HIV\u2010exposed and HIV\u2010uninfected (HEU) infants may be at increased risk of poor health and growth outcomes. We characterized infant growth trajectories in a cohort of HEU infants to identify factors associated with healthy growth. HIV\u2010positive women participating in prevention of mother\u2010to\u2010child HIV transmission programmes in Kigali, Rwanda, were followed until their infants were 2\u00a0years old. Infant anthropometrics were regularly collected. Latent class analysis was used to categorize infant growth trajectories. Multiple logistic regression was used to estimate the odds of infants belonging to each growth trajectory class. On average, this population of HEU infants had moderate linear growth faltering, but only modest faltering in weight, resulting in mean weight\u2010for\u2010length <jats:italic>z<\/jats:italic>\u2010score (WLZ) above the World Health Organization (WHO) median. Mean WLZ was 0.53, and mean length\u2010for\u2010age <jats:italic>z<\/jats:italic>\u2010score (LAZ) was \u22121.14 over the first 2\u00a0years of life. We identified four unique WLZ trajectories and seven trajectories in LAZ. Low neonatal weight\u2010for\u2010age and a high rate of illness increased the likelihood that infants were in the lightest WLZ class. Shorter mothers were more likely to have infants with linear growth faltering. Female infants who were older at the end of exclusive breastfeeding were more likely to be in the second tallest LAZ class. In conclusion, the current WHO recommendations of Option B+ and extended breastfeeding may induce higher WLZ and lower LAZ early in infancy. However, there is considerable heterogeneity in growth patterns that is obscured by simply analysing average growth trends, necessitating the analysis of growth in subpopulations.<\/jats:p>","DOI":"10.1111\/mcn.12776","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T19:20:12Z","timestamp":1546629612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Determinants of growth in <scp>HIV<\/scp>\u2010exposed and <scp>HIV<\/scp>\u2010uninfected infants in the <scp>K<\/scp>abeho <scp>S<\/scp>tudy"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-6687","authenticated-orcid":false,"given":"Charlotte E.","family":"Lane","sequence":"first","affiliation":[{"name":"Nutrition Department The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Bobrow","sequence":"additional","affiliation":[{"name":"Nutrition Department The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diuedonne","family":"Ndatimana","sequence":"additional","affiliation":[{"name":"Elizabeth Glaser Pediatric AIDS Foundation  Kigali Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles F.","family":"Ndayisaba","sequence":"additional","affiliation":[{"name":"Elizabeth Glaser Pediatric AIDS Foundation  Kigali Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"Adair","sequence":"additional","affiliation":[{"name":"Nutrition Department The University of North Carolina at Chapel Hill  Chapel Hill North Carolina 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