{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:13:33Z","timestamp":1787879613994,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between maternal folic acid supplementation in pregnancy and infant birthweight has not been well described in low\u2010 and middle\u2010income countries. We conducted a systematic review and meta\u2010analysis of the current evidence of the association between folic acid supplementation in pregnancy on three primary outcomes: the incidence of low birthweight, small for gestational age, and mean birthweight. Seventeen studies were identified, which satisfied the inclusion criteria, covering a total of 275,421 women from 13 cohort studies and four randomized controlled trials. For the primary outcome of mean birthweight (<jats:italic>n<\/jats:italic> = 9), the pooled mean difference between folic acid and control groups was 0.37 kg (95% confidence interval [CI]: 0.24 to 0.50), and this effect was larger in the randomized controlled trials (0.56, 95% CI: 0.15 to 0.97, <jats:italic>n<\/jats:italic> = 3). The pooled odds ratio was 0.59 for low birthweight (95% CI: 0.47 to 0.74, <jats:italic>n<\/jats:italic> = 10) among folic acid supplementation versus control. The pooled odds ratio for the association with small for gestational age was 0.63 (95% CI: 0.39 to 1.01, <jats:italic>n<\/jats:italic> = 5). Maternal folic acid supplementation in low\u2010 and middle\u2010income countries was associated with an increased mean birthweight of infants and decreases in the incidence of low birthweight and small for gestational age.<\/jats:p>","DOI":"10.1111\/mcn.12895","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T09:02:34Z","timestamp":1572858154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Maternal folic acid supplementation and infant birthweight in low\u2010 and middle\u2010income countries: A systematic review"],"prefix":"10.1111","volume":"16","author":[{"given":"Hannah","family":"Jonker","sequence":"first","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Midwifery Research Centre, McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Capelle","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lanes","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Wu","family":"Wen","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Obstetrics, Gynecology &amp; Newborn Care University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Walker","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Obstetrics, Gynecology &amp; Newborn Care University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7063-3354","authenticated-orcid":false,"given":"Daniel J.","family":"Corsi","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"},{"name":"Children's Hospital of Eastern Ontario Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-498"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(95)02325-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002966511200256X"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.172015"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2010.01.005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-012-0217-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7389.571"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.056382"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184.ch8"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"132","article-title":"Incidence, correlates and outcomes of low birth weight\u2014A one year longitudinal study","volume":"2","author":"Joseph N.","year":"2011","journal-title":"Indian Journal of Public Health Research & Development"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3086-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265120332S107"},{"issue":"5","key":"e_1_2_11_14_1","first-page":"600","article-title":"Maternal nutrition & low birth weight\u2014What is really important","volume":"130","author":"Muthayya S.","year":"2009","journal-title":"The Indian Journal of Medical Research"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90125-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-898"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001608"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(98)00178-X"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.4.1217"},{"issue":"4","key":"e_1_2_11_20_1","first-page":"838","article-title":"Prevalence and risk factors of low\u2010birth\u2010weight infants in Zahedan, Islamic Republic of Iran","volume":"13","author":"Roudbari M.","year":"2007","journal-title":"Eastern Mediterranean Health Journal"},{"key":"e_1_2_11_21_1","unstructured":"Stavis R.(2017).Small\u2010for\u2010gestational\u2010age (SGA) infant. 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