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This study aimed to investigate whether breast milk iodine concentration (BMIC) is associated with growth\u2010 and obesity\u2010related hormones and subsequently the infants' anthropometric measures. In present study conducted in Tehran (Iran), 94 lactating mothers and healthy infants who were exclusively breastfed were included. Concentrations of iodine, insulin\u2010like growth factor\u20101 (IGF\u20101), adiponectin (AD) and leptin (LP) were measured in breast milk samples collected during 3\u2010 to 5\u2010day postpartum. Anthropometric measures of infants were assessed at 6 months of life, and age\u2010 and sex\u2010specific <jats:italic>z<\/jats:italic>\u2010score values were calculated using the World Health Organization growth standards. The median (interquartile range) iodine, IGF\u20101, AD and LP concentrations were 232.5 (157.5\u2013296.0) \u03bcg L<jats:sup>\u22121<\/jats:sup>, 15.7 (11.9\u201321.1) ng ml<jats:sup>\u22121<\/jats:sup>, 13.2 (5.1\u201329.8) mg L<jats:sup>\u22121<\/jats:sup> and 1.16 (0.86\u20131.70) ng ml<jats:sup>\u22121<\/jats:sup> in breast milk, respectively. No significant correlations were found between BMIC and IGF\u20101, AD and LP concentrations during the first few days postpartum. In adjusted regression model, BMIC was positively associated with weight\u2010for\u2010length <jats:italic>z<\/jats:italic> score of infants. In the presence of IGF\u20101, AD or LP, the coefficients of BMIC for weight\u2010for\u2010length <jats:italic>z<\/jats:italic> score of infants were <jats:italic>\u03b2<\/jats:italic> = .003 (<jats:italic>P<\/jats:italic> = .021), <jats:italic>\u03b2<\/jats:italic> = .002 (<jats:italic>P<\/jats:italic> = .028) or <jats:italic>\u03b2<\/jats:italic> = .003 (<jats:italic>P<\/jats:italic> = .013), respectively. No other anthropometric measurements were associated with iodine or growth\u2010 and obesity\u2010related hormones in breast milk. Our findings indicate that BMIC is a potential contributor to infants' growth status, independent of IGF\u20101, AD or LP concentrations in breast milk. The underlying mechanisms remain to be elucidated.<\/jats:p>","DOI":"10.1111\/mcn.13078","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T11:37:08Z","timestamp":1601379428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is breast milk iodine concentration an influential factor in growth\u2010 and obesity\u2010related hormones and infants' growth parameters?"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1422-5142","authenticated-orcid":false,"given":"Pantea","family":"Nazeri","sequence":"first","affiliation":[{"name":"Family Health Institute, Breastfeeding Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhale","family":"Tahmasebinejad","sequence":"additional","affiliation":[{"name":"Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-775X","authenticated-orcid":false,"given":"Mehdi","family":"Hedayati","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2391-4924","authenticated-orcid":false,"given":"Parvin","family":"Mirmiran","sequence":"additional","affiliation":[{"name":"Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-2517","authenticated-orcid":false,"given":"Fereidoun","family":"Azizi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03442.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/17477160902763309"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70155-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2014.222.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.189"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.242560"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01192.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020358"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21519"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5554"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13350"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367998"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.124719"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2011.08.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486493"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081845"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.155"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","unstructured":"Murray P. 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