{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:48:03Z","timestamp":1779925683686,"version":"3.53.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["Salud\u20102002\u2010C01\u20106532"],"award-info":[{"award-number":["Salud\u20102002\u2010C01\u20106532"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["Salud\u20102002\u2010C01\u20136532"],"award-info":[{"award-number":["Salud\u20102002\u2010C01\u20136532"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to identify serum ferritin (SF) cut\u2010off points (COPs) in a cohort of healthy full\u2010term normal birth weight infants who had repeated measurements of SF and haemoglobin every 3\u2009months during the first year of life. The study included 746 full\u2010term infants with birth weight \u22652,500\u2009g, having uncomplicated gestations and births. Participants received prophylactic iron supplementation (1\u00a0mg\/day of iron element) from the first to the 12th month of life and did not develop anaemia during the first year of life.<\/jats:p><jats:p>Two statistical methods were considered to identify COPs for low iron stores at 3, 6, 9 and 12\u2009months of age:<jats:italic>deviation from mean<\/jats:italic>and<jats:italic>cluster analysis<\/jats:italic>. According to the<jats:italic>K\u2010means cluster analysis<\/jats:italic>results by age and sex, COPs at 3 and 6\u2009months for girls were 39 and 21\u2009\u03bcg\/L and for boys 23 and 11\u2009\u03bcg\/L, respectively. A single COP of 10\u00a0\u03bcg\/L was identified, for girls and boys, at both 9 and 12\u2009months. Given the physiological changes in SF concentration during the first year of life, our study identified dynamic COPs, which differed by sex in the first semester. Adequate SF COPs are necessary to identify low iron stores at an early stage of iron deficiency, which represents one of the most widespread public health problems around the world, particularly in low\u2010 and middle\u2010income countries.<\/jats:p>","DOI":"10.1111\/mcn.13205","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T03:46:06Z","timestamp":1622000766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cut\u2010off points for serum ferritin to identify low iron stores during the first year of life in a cohort of Mexican infants"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4777-1414","authenticated-orcid":false,"given":"Azucena","family":"P\u00e9rez\u2010Acosta","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Infecciosas y Parasitarias, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7630-0259","authenticated-orcid":false,"given":"Ximena","family":"Duque","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Infecciosas y Parasitarias, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-0078","authenticated-orcid":false,"given":"Belem","family":"Trejo\u2010Valdivia","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Nutrici\u00f3n y Salud Instituto Nacional de Salud P\u00fablica Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-4721","authenticated-orcid":false,"given":"Samuel","family":"Flores\u2010Huerta","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Salud Comunitaria, Hospital Infantil de M\u00e9xico Federico G\u00f3mez Instituto Nacional de Salud Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-9234","authenticated-orcid":false,"given":"Sergio","family":"Flores\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Evaluaci\u00f3n y Encuestas Instituto Nacional de Salud P\u00fablica Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4579-9819","authenticated-orcid":false,"given":"Gloria","family":"Mart\u00ednez\u2010Andrade","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Epidemiol\u00f3gica y en Servicios de Salud Instituto Mexicano del Seguro Social Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-8456","authenticated-orcid":false,"given":"Marco","family":"Gonz\u00e1lez\u2010Unzaga","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Epidemiolog\u00eda Nutricional Instituto Mexicano del Seguro Social Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-913X","authenticated-orcid":false,"given":"Bernardo","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Acad\u00e9mico de tiempo Universidad Iberoamericana Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka","family":"Escalante\u2010Izeta","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud Universidad Iberoamericana San Andr\u00e9s Cholula Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-8366","authenticated-orcid":false,"given":"Miguel","family":"Kl\u00fcnder\u2010kl\u00fcnder","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n, Hospital Infantil de M\u00e9xico Federico G\u00f3mez Instituto Nacional de Salud Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Carranco\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Prestaciones Econ\u00f3micas y Sociales, Coordinaci\u00f3n del Servicio de Guarder\u00eda para el Desarrollo Integral Infantil, Divisi\u00f3n de Desarrollo Integral Infantil Instituto Mexicano del Seguro Social Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-0644","authenticated-orcid":false,"given":"Eugenia","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Infecciosas y Parasitarias, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2267-2062","authenticated-orcid":false,"given":"Elma Ivonne","family":"Sotelo\u2010Ham","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n Delegacional de Investigaci\u00f3n de Zacatecas Instituto Mexicano del Seguro Social Zacatecas M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Pineda","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Epidemiolog\u00eda Cl\u00ednica Instituto Mexicano del Seguro Social Colima M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1203-1552","authenticated-orcid":false,"given":"Carolina","family":"Medina\u2010Escobedo","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Educaci\u00f3n e Investigaci\u00f3n en Salud. Unidad M\u00e9dica de Alta Especialidad, Hospital de Especialidades Centro M\u00e9dico Nacional \u201cIgnacio Garc\u00eda T\u00e9llez\u201d en M\u00e9rida Instituto Mexicano del Seguro Social M\u00e9rida M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-0306","authenticated-orcid":false,"given":"Homero","family":"Martinez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Hospital Infantil de M\u00e9xico Federico G\u00f3mez Instituto Nacional de Salud Ciudad de M\u00e9xico M\u00e9xico"},{"name":"Global Technical Services Nutrition International Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200204000-00003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-08-043076-7\/00764-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2012.04.020"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.199"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.177741"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155960"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-36342012000200006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.21149\/8824"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.182527"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000206"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112895"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.12.3680"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.3.545"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-345"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470977811"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2018.12.005"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8060330"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.020"},{"key":"e_1_2_11_20_1","volume-title":"Four\u2010factor index of social status","author":"Hollingshead A. B.","year":"1975"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155895"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1681028"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.014"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540360041028"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.4.e51"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.160.11.1108"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.22.1_supplement.895.5"},{"issue":"12","key":"e_1_2_11_28_1","first-page":"770","article-title":"13C urea breath test for (Helicobacter pylori): determination of the optimal cut\u2010off point in a Canadian community population","volume":"20","author":"Mauro M.","year":"2006","journal-title":"Canadian Journal of Gastroenterology & Hepatology"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-1"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2018.1482256"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000074"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8110693"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155887"},{"issue":"2","key":"e_1_2_11_34_1","first-page":"96","article-title":"Comparison of two statistical methods to determine normal range of androgen hormones: K\u2010means cluster analysis and receiver operating characteristic curve","volume":"12","author":"Ramezani\u2010Tehrani F.","year":"2018","journal-title":"The Journal of Family & Reproductive Health"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150750"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.6.1180"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1978.tb16254.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100805"},{"issue":"6","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000014114","article-title":"Gender difference in cord serum ferritin concentrations","volume":"75","author":"Tamura T.","year":"1999","journal-title":"Neonatology"},{"issue":"450","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1651-2227.2006.tb02378.x","article-title":"WHO Child Growth Standards based on length\/height, weight and age","author":"WHO Multicentre Growth Reference Study Group","year":"2006","journal-title":"Acta Paediatrica (Oslo, Norway:1992)"},{"key":"e_1_2_11_41_1","unstructured":"WHO. (2007).Assessing the iron status of populations: Including literature reviews. Report of a joint World Health Organization\/Centers for Disease Control and Prevention technical consultation on the assessment of iron status at the population level Geneva Switzerland 6\u20138 April 2004. Geneva: World Health Organization.https:\/\/apps.who.int\/iris\/handle\/10665\/75368"},{"key":"e_1_2_11_42_1","unstructured":"WHO. (2008).Indicators for assessing infant and young child feeding practices: Part 1: definitions: Conclusions of a consensus meeting held 6\u20138 November 2007 in Washington DC USA."},{"key":"e_1_2_11_43_1","unstructured":"WHO. (2011).Serum ferritin concentrations for the assessment of iron status and iron deficiency in population. Retrieved 23 March 2020 from:https:\/\/apps.who.int\/iris\/handle\/10665\/85843"},{"key":"e_1_2_11_44_1","volume-title":"The global prevalence of anemia in 2011","author":"WHO","year":"2015"},{"key":"e_1_2_11_45_1","volume-title":"Nutritional anaemias: tools for effective prevention and control","author":"World Health Organization","year":"2017"},{"key":"e_1_2_11_46_1","volume-title":"Global anaemia reduction efforts among women of reproductive age: impact, achievement of targets and the way forward for optimizing efforts","author":"World Health Organization","year":"2020"},{"issue":"11","key":"e_1_2_11_47_1","first-page":"829","article-title":"Cut\u2010off Values of Diagnostic Indices to Detect Iron Deficiency in Chinese Breast\u2010fed Infants","volume":"29","author":"Wu Q.","year":"2016","journal-title":"Biomedical and Environmental Sciences: BES"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.10.021"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04395.x"}],"container-title":["Maternal &amp; Child Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mcn.13205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mcn.13205","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mcn.13205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T04:50:17Z","timestamp":1699073417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mcn.13205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/mcn.13205"],"URL":"https:\/\/doi.org\/10.1111\/mcn.13205","archive":["Portico"],"relation":{},"ISSN":["1740-8695","1740-8709"],"issn-type":[{"value":"1740-8695","type":"print"},{"value":"1740-8709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"2020-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13205"}}