{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:24:34Z","timestamp":1777325074314,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the MITICA (Mother\u2010to\u2010Infant TransmIssion of microbiota in Central\u2010Africa) study, 48 mothers and their 50 infants were followed from delivery to 6\u00a0months between December 2017 and June 2019 in Bangui (Central\u2010African Republic). Blood tests and stool analyses were performed in mothers at delivery, and their offspring at birth, 11\u2009weeks and 25\u2009weeks. Stool cultures were performed in specific growth media for <jats:italic>Salmonella<\/jats:italic>, <jats:italic>Shigella<\/jats:italic>, <jats:italic>E. coli<\/jats:italic>, <jats:italic>Campylobacter<\/jats:italic>, <jats:italic>Enerobacter<\/jats:italic>, <jats:italic>Vibrio cholerae<\/jats:italic>, <jats:italic>Citrobacter<\/jats:italic> and <jats:italic>Klebsiella<\/jats:italic>, as well as rotavirus, yeasts and parasitological exams. The median vitamin C levels in mothers at delivery were 15.3\u00a0\u03bcmol\/L (inter\u2010quartile\u2010range [IQR] 6.2\u201327.8\u00a0\u03bcmol\/L). In infants, the median vitamin C levels at birth were 35.2\u00a0\u03bcmol\/L (IQR 16.5\u201363.9\u00a0\u03bcmol\/L). At 11 and 25\u2009weeks, the median vitamin C levels were 41.5\u00a0\u03bcmol\/L (IQR 18.7\u201371.6\u00a0\u03bcmol\/L) and 18.2\u00a0\u03bcmol\/L (IQR 2.3\u201346.6\u00a0\u03bcmol\/L), respectively. Hypovitaminosis C was defined as seric vitamin C levels &lt;28\u2009\u03bcmol\/L and vitamin C deficiency was defined as vitamin C levels &lt;11\u2009\u03bcmol\/L according to the WHO definition. In mothers, the prevalence of hypovitaminosis\u2010C and vitamin C deficiency at delivery was 34\/45 (75.6%) and 19\/45 (42.2%), respectively. In infants, the prevalence of hypovitaminosis\u2010C and vitamin C deficiency at 6\u00a0months was 18\/33 (54.6%) and 11\/33 (33.3%), respectively. Vitamin C levels in mothers and infants were correlated at birth (Spearman's rho\u2009=\u20090.5; <jats:italic>P<\/jats:italic> value\u2009=\u20090.002), and infants had significantly higher levels of vitamin C (median\u2009=\u200935.2\u00a0\u03bcmol\/L; IQR 16.5\u201363.9\u00a0\u03bcmol\/L), compared to mothers (median\u2009=\u200915.3\u00a0\u03bcmol\/L; IQR 6.2\u201327.8\u00a0\u03bcmol\/L; <jats:italic>P<\/jats:italic> value &lt;0.001). The offspring of vitamin C\u2010deficient mothers had significantly lower vitamin C levels at delivery (median\u2009=\u200918.7\u00a0\u03bcmol\/L; IQR 13.3\u201330.7\u00a0\u03bcmol\/L), compared to the offspring of non\u2010deficient mothers (median\u2009=\u200962.2\u00a0\u03bcmol\/L; IQR 34.6\u201389.2\u00a0\u03bcmol\/L; <jats:italic>P<\/jats:italic> value &lt;0.001). Infants with hypovitaminosis\u2010C were at significantly higher risk of having a positive stool culture during the first 6\u00a0months of life (adjusted OR\u2009=\u20095.3, 95% CI 1.1; 26.1; <jats:italic>P<\/jats:italic> value\u2009=\u20090.038).<\/jats:p>","DOI":"10.1111\/mcn.13215","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T08:45:20Z","timestamp":1623919520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vitamin C levels in a Central\u2010African mother\u2013infant cohort: Does hypovitaminosis C increase the risk of enteric infections?"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-2263","authenticated-orcid":false,"given":"Violeta","family":"Moya\u2010Alvarez","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Pathog\u00e9nie Microbienne Mol\u00e9culaire, INSERM U1202, Department of Cell Biology and Infection Institut Pasteur  Paris France"},{"name":"Epidemiology of Emergent Diseases Unit, Global Health Department Institut Pasteur  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Christophe Junior","family":"Koyembi","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Epid\u00e9miologie Institut Pasteur de Bangui  Bangui Central\u2010African Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure M.","family":"Kay\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire des Virus Ent\u00e9riques\/Rougeole Institut Pasteur de Bangui  Bangui Central\u2010African Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-7755","authenticated-orcid":false,"given":"Jean\u2010Robert","family":"Mbecko","sequence":"additional","affiliation":[{"name":"Laboratoire de bact\u00e9riologie m\u00e9dicale et exp\u00e9rimentale Institut Pasteur de Bangui  Bangui 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