{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:59:23Z","timestamp":1790891963981,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","award":["HHSN275201100001"],"award-info":[{"award-number":["HHSN275201100001"]}],"id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","award":["HHSN27500009"],"award-info":[{"award-number":["HHSN27500009"]}],"id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prior research suggests that severe iodine deficiency in pregnancy may be associated with stillbirth. However, the relationship between mild to moderate iodine insufficiency, which is prevalent even in developed countries, and risk of stillbirth is unclear. We thus examined associations of iodine status and risk of stillbirth in a prospective population\u2010based nested case\u2013control study in Finland, a mild to moderately iodine insufficient population. Stillbirth cases (<jats:italic>n<\/jats:italic>\u2009=\u2009199) and unaffected controls (<jats:italic>n<\/jats:italic>\u2009=\u2009249) were randomly selected from among all singleton births in Finland from 2012 to 2013. Serum samples were collected between 10 and 14\u2009weeks gestation and analysed for iodide, thyroglobulin (Tg) and thyroid\u2010stimulating hormone (TSH). Odds ratios (ORs) and 95% confidence intervals (CIs) for stillbirth were estimated using logistic regression. After adjusting for maternal age, prepregnancy body mass index, socio\u2010economic status and other factors, neither high nor low serum iodide was associated with risk of stillbirth (Q1 vs. Q2\u2013Q3 OR\u2009=\u20090.92, 95% CI\u2009=\u20090.78\u20131.09; Q4 vs. Q2\u2013Q3 OR\u2009=\u20090.78; 95% CI\u2009=\u20090.45\u20131.33). Tg and TSH were also not associated with risk of stillbirth in adjusted models. Maternal iodine status was not associated with stillbirth risk in this mildly to moderately iodine\u2010deficient population. Tg and TSH, which reflect functional iodine status, were also not associated with stillbirth risk. The lack of associations observed between serum iodide, TSH and Tg and risk of stillbirth is reassuring, given that iodine deficiency in pregnancy is prevalent in developed countries.<\/jats:p>","DOI":"10.1111\/mcn.13252","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T06:15:07Z","timestamp":1628144107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Iodine and thyroid status during pregnancy and risk of stillbirth: A population\u2010based nested case\u2013control study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-3651","authenticated-orcid":false,"given":"Alexandra C.","family":"Purdue\u2010Smithe","sequence":"first","affiliation":[{"name":"Division of Intramural Population Health Research, National Institutes of Health <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuija","family":"M\u00e4nnist\u00f6","sequence":"additional","affiliation":[{"name":"Northern Finland Laboratory Center NordLab Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah","family":"Reische","sequence":"additional","affiliation":[{"name":"Division of Intramural Population Health Research, National Institutes of Health <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurunthachalam","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Environmental Medicine New York University School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Un\u2010Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Earth and Environmental Sciences University of Texas at Arlington  Arlington Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eila","family":"Suvanto","sequence":"additional","affiliation":[{"name":"Oulu University Hospital, Department of Children and Women and Oulu University Medical Faculty PEDEGO Research Unit Medical Research Center  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helj\u00e4\u2010Marja","family":"Surcel","sequence":"additional","affiliation":[{"name":"Biobank Borealis of Northern Finland Oulu University Hospital  Oulu Finland"},{"name":"Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"Information Services Department Finnish Institute of Health and Welfare  Helsinki Finland"},{"name":"Department of Neurobiology Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Mills","sequence":"additional","affiliation":[{"name":"Division of Intramural Population Health Research, National Institutes of Health <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.4.6496"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13523"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.Aog.0000262054.03531.24"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.12211"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy325"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00954-X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb13305.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-49505-7_3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0353"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13421"},{"issue":"4","key":"e_1_2_10_13_1","first-page":"356","article-title":"Iodine deficiency in relation to the stillbirth problem","volume":"41","author":"Kemp W. N.","year":"1939","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.144071"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2011.08.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3591"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0337"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v60.31969"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1101443"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13945"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.110429"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/8.2.137"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112573"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600762"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14971"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf03350244"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2829"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0274"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332762"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2018.01.013"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2018.1512150"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3952"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61005-3"}],"container-title":["Maternal &amp; Child Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mcn.13252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mcn.13252","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mcn.13252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:37:02Z","timestamp":1693193822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mcn.13252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,4]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/mcn.13252"],"URL":"https:\/\/doi.org\/10.1111\/mcn.13252","archive":["Portico"],"relation":{},"ISSN":["1740-8695","1740-8709"],"issn-type":[{"value":"1740-8695","type":"print"},{"value":"1740-8709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,4]]},"assertion":[{"value":"2021-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13252"}}