{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:00:46Z","timestamp":1790377246284,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Micronutrient supplementation is widely used to prevent stunting in children under 5\u2009years in low\u2010 and middle\u2010income countries (LMIC), but the impact of treatment has been disappointing, possibly due to non\u2010compliance. Our aim was to deliver long\u2010term micronutrient supplementation via a novel, culturally acceptable liquid food to improve linear growth in a high stunting prevalence region.<\/jats:p><jats:p>In a randomised control trial, 971 children aged 6\u201372\u2009months received either \u2018Chispuditos\u00ae\u2019 (<jats:italic>n<\/jats:italic>\u2009=\u2009681), a hot drink (atole) fortified with micronutrients (atole\u2009+\u2009MN) (9\u00a0mg\/zinc, 12.5\u00a0mg\/iron), or lactose\u2010free milk (<jats:italic>n<\/jats:italic>\u2009=\u2009290) for 18\u2009months. Primary outcomes were changes in length\/height\u2010for\u2010age (HAZ) score and the prevalence of stunting at 18\u2010month follow\u2010up. Adherence was monitored monthly, and 73% children in atole\u2009+\u2009MN group consumed at least half their daily zinc and iron requirement. At 18\u2009months, there was no difference between the treatments in growth [mean change in HAZ \u22120.02 (95% CI \u22120.12, 0.08)] or stunting [atole\u2009+\u2009MN 41%, milk 41%; RR 0.99 (95% CI 0.84, 1.19)]. There were no differences in haemoglobin (HB), ferritin or zinc. No children had iron deficiency anaemia (IDA) at outcome, but zinc deficiency remained equally prevalent in both groups: atole\u2009+\u2009MN 35%, milk 35% [RR 1.02 (95% CI 0.83, 1.24)]. There was no difference in morbidity between the groups, and micronutrient status was unrelated to HAZ. Long\u2010term micronutrient supplementation via a culturally acceptable food had no impact on stunting or morbidity, raising the question of whether large\u2010scale micronutrient supplementation is worthwhile.<\/jats:p>","DOI":"10.1111\/mcn.13256","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T08:09:58Z","timestamp":1628237398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Childhood stunting and micronutrient status unaffected by RCT of micronutrient fortified drink"],"prefix":"10.1111","volume":"18","author":[{"given":"Victor","family":"Alfonso May\u00e9n","sequence":"first","affiliation":[{"name":"Association for the Prevention and Study of HIV\/AIDS (APEVIHS)  Retalhuleu Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abimbola","family":"Ogunlusi","sequence":"additional","affiliation":[{"name":"Human Nutrition, School of Medicine, Dentistry &amp; Nursing University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-6315","authenticated-orcid":false,"given":"Charlotte Margaret","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Child Health, School of Medicine, Dentistry &amp; Nursing University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3526-2380","authenticated-orcid":false,"given":"Ada Lizbeth","family":"Garcia","sequence":"additional","affiliation":[{"name":"Human Nutrition, School of Medicine, Dentistry &amp; Nursing University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"2020 Global Nutrition Report: Action on equity to end Malnutrition. 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